Paracetamol 200 mg tablet instructions for use. Medicinal reference book geotar. General characteristics. Compound

Family doctor, nutritionist. Head of the branch in medical network“Healthy Generation”.

The instructions for use of paracetamol regulate it as an analgesic and antipyretic. It is used for colds, ARVI and other diseases accompanied by hyperthermia. The drug is suitable for all age categories, but the rules of use and dosage differ significantly.
Take orally 1-1.5 hours after meals, with a large volume of liquid. The dosage of Paracetamol is as follows:

adults and adolescents over 12 years of age (body weight over 40 kg) take 2.5-5 tablets of 200 mg or 1-2 tablets of 500 mg;
Children from 6 to 12 years old are prescribed 1 tablet of 200 mg or 1/2-1 tablet of 500 mg.

Children under 6 years of age are advised to use syrup or rectal suppositories.
Do not take the product at the same time as other medications containing paracetamol (AntiFlu, Antigrippin, Grippostad, Ibuklin, Coldrex, Maxicold, etc.). Use with caution when:

viral hepatitis;
alcoholic liver damage;
alcoholism;
pregnancy and lactation.

In tablets, the main substance is paracetamol (500 mg). Additionally, the drug contains the following components:

stearic acid (3.3 mg);
corn and potato starch (25.8 mg);
gelatin (1.4 mg);
organic sodium compounds (24 mg).

Manufacturers offer tablets with active ingredient concentrations of 200 and 500 mg. The first option is used to normalize temperature in children, and a more concentrated product is used for adults.

Paracetamol tablets for adults

Instructions for use will allow the use of paracetamol tablets if, when measuring temperature, the thermometer readings are above 38-38.5 degrees. Admission is subject to the following rules:

single dosage – 500-1000 mg (maximum two tablets);
take the drug with plenty of water;
consume after meals, after half an hour;
course – maximum 5 days;
No more than 4 doses per day are allowed at intervals of 4-6 hours.

Note! For patients diagnosed with cirrhosis of the liver with impaired functionality of the organ, the dosage should be selected by a doctor. In addition, with dysfunction of this organ, the half-life of paracetamol increases by 2 times, which increases the toxic load.

Paracetamol tablets for children - instructions for use

200 mg tablets are used for children with the following indications:

hyperthermia;
headache;
muscle and joint pain;
toothache;
ARVI symptoms.

According to the instructions for use, the dosage of Paracetamol tablets for children is calculated according to the formula on an individual basis. Factors such as age category, body weight (10 mg/kg) and health conditions are taken into account:

infants up to 1 year – from 50 to 100 mg;
up to three years – 100 to 150 mg;
up to 6 years – from 150 to 200 mg;
from 6 to 12 years – 200-400 mg.

The drug is washed down with water and taken after meals. For babies and young children preschool age It is permissible to grind the tablet into powder and prepare a small amount of an aqueous solution with added sugar.

Paracetamol tablets for fever

If body temperature rises, paracetamol should be taken according to the instructions for use:

Take tablets only at 38 degrees and above in children and from 38.5 in adults.
The time before re-use is at least 4-6 hours.
For people with liver disease, a break of at least 8 hours.
You should not combine medication with alcohol.
The use of the product in combination with other paracetamol-based medications is strictly prohibited.

After taking the pills, you should avoid hypothermia. Exceeding doses is unacceptable.

Overdose symptoms:

nausea and vomiting;
abdominal pain;
pallor;
loss of appetite;
renal colic;
dizziness;
loss of consciousness.

If symptoms of overdose occur, urgent detoxification of the body is necessary in a hospital setting. If the norm is slightly exceeded, you can eliminate the consequences by taking activated carbon.

If paracetamol does not work, then you need to call doctors from the emergency room for an injection of the complex drug.

Paracetamol for children - instructions for use

Paracetamol is effective in symptomatic therapy, so prescribing the drug does not cancel the main course. Indications:

increased body temperature;
pain syndrome (caries, teething, headache when overexerting).

You cannot take paracetamol for a long time for toothaches and headaches, since the drug only relieves symptoms, but does not eliminate the underlying disease.
For ARVI, taking paracetamol not only eliminates pain and hyperthermia, but also improves the general condition.
The drug is taken after meals (after 1-2 hours) and washed down with plenty of liquid. If the child has difficulty swallowing the tablet, it can be crushed. Paracetamol in tablet form is allowed for children from 3 years of age:

3-6 years - 100-200 mg per dose;
6-12 years - 200-400 mg.

If the child has a high fever, the medicine can be taken for 3-5 days. If symptoms persist or worsen, be sure to consult a doctor.
In addition, syrup, suspension and suppositories are used in pediatrics for children under 3 years of age. The antipyretic effect occurs much faster when taking syrup, and lasts longer when using suppositories.
Note! For infants, the dosage is calculated depending on weight: 10-15 mg of active substance per 1 kg of body weight.
You can take it 3-4 times a day, maintaining an interval of 4-6 hours.

Children's syrup Paracetamol - instructions for use

The drug is available in bottles, contains glucose and is therefore used with caution in the treatment of patients with diabetes. Concentration in syrup is 120 mg of active ingredient for every 5 ml.
Dosage of paracetamol syrup for children

Age	Weight	Single dose	Maximum daily dose
2 – 3 months	4 – 6 kg	2.5 ml	10 ml
3 – 6 months	6 – 8 kg	4 ml	16 ml
6 – 12 months	8 – 12 kg	5 ml	20 ml
1 – 2 years	12 – 14 kg	7 ml	28 ml
2 – 3 years	14 – 16 kg	9 ml	36 ml
36 years	16 – 21 kg	10 ml	40 ml
6 – 9 years	21 – 29 kg	14 ml	56 ml
9 – 12 years	24 – 42 kg	20 ml	80 ml

It is forbidden to increase the dose, since Negative consequences For child's body may be irreversible.
For children over 12 years of age, the drug is used in tablets.
Contraindications to the use of syrup:

allergy to the components of the product;
liver failure;
leukopenia;
thrombocytopenia.

Use syrup with caution for viral hepatitis and congenital defects hearts.

Paracetamol suspension for children - instructions for use

For young children, it is advisable to use paracetamol in suspension. According to the instructions for use, paracetamol suspension for children is used in the following doses:

Up to 3 years – 0.5 scoop (2.5 ml).
From 3 to 6 years – 5 ml.
Children over 6 years old – 7.5 -10 ml.

It is important to maintain an interval of at least 4 hours. If there is no effectiveness, antispasmodics are taken along with paracetamol. The following undesirable effects may develop from taking the suspension:

rash and itching;
nausea;
vomit;
diarrhea;
intestinal colic;
loss of appetite;
dizziness.

In case of overdose, an increase in the listed symptoms and intoxication syndrome is observed. It is necessary to perform gastric lavage and seek emergency help.

Instructions for use of Paracetamol for colds

Paracetamol makes cold symptoms less severe. Dosages are calculated individually taking into account weight and availability concomitant diseases. For every kilogram of human weight no more than 10 mg. At liver failure the dose should be reduced by 2 times, and the interval between doses should be increased. Instructions for use:

take tablets at temperatures above 38 degrees;
no more than 4 times a day;
interval between doses – from 4 hours;
maximum duration of use is 5 days.

If you need to take paracetamol for longer, it is important to consult your doctor to assess the potential benefit versus risk.

Paracetamol tablets 0.5 g effectively eliminate chills, reduce body temperature and have a pronounced analgesic effect.
Adults and children over 12 years of age are prescribed 500–1000 mg every 4 hours. The maximum daily dose is 4000 mg.
If it is necessary to use this dosage in children under 12 years of age, a single dose is calculated based on the child’s weight: a maximum of 10 mg per kg of body weight. You can crush the tablet and add water to make it easier for your child to swallow. Do not exceed the children's dosage, as this will negatively affect the child's body.

The shelf life of the product is no more than 3 years from the date of release. It is dangerous to use tablets if they were stored outside the blister or if the shelf life has expired.

Features of use:

do not combine with ethanol due to the risk of damage to the pancreas;
do not take with barbiturates (Corvalol, Barboval);
do not take longer than 5 days due to risk of bleeding.

If symptoms of intolerance occur after taking the drug, you should call a doctor. The risk of liver damage from overdose increases with simultaneous administration with other hepatotoxic substances.

Tablets with a dosage of 200 mg are taken an hour after a meal, washed down with liquid. large volumes. For symptomatic treatment is used according to this scheme:

daily dose – not higher than 5 g;
recommended dosage – from 2 tablets per 1 dose;
frequency of use – 3-4 times a day.

On the third day of use, it is necessary to reduce the dosage or increase the time interval between acts of use. After 4 days, you must stop taking paracetamol due to the risk of unwanted complications.

Paracetamol 200 - instructions for use for children

The drug with a dosage of 200 mg is intended for children. Instructions for use of children's paracetamol :

Children over 3 years old – 1/2 or 1/4 tablet every 4-5 hours;
Children over 6 years old – 1/2 or a whole tablet with the same frequency.

Children over 12 years old take paracetamol 500 mg 1 tablet or 2.5 tablets of the drug with a concentration of 200 mg. Indications for use:

heat;
pain syndrome;
myalgia;
migraine;
toothache.

Paracetamol 200 mg is contraindicated in case of individual intolerance and liver dysfunction. Use with caution in patients with diseases of the hematopoietic system.

Paracetamol-based suppositories are used in pediatrics. Dosage of Paracetamol suppositories for children, taking into account age differences.

Administer suppositories no more than 4 times a day with an interval of 4-6 hours.

Candles should be used in the following conditions:

temperature from 38 degrees;
pain during teething;
headache.

Candles should be stored in a cool place; before use, warm the individual packaging in your hand. Directions for use: open the plastic packaging and insert into anus.

Important! If a child's body temperature is above 39.5 degrees, it is dangerous to use candles! At this stage, blood vessels spasm as a result of rapid centralization of blood circulation. Therefore, the active components of the product are not absorbed!

Paracetamol MS - instructions for use

Paracetamol MS - tablets from Russian pharmaceutical company"Medisorb". The drug contains paracetamol and additional ingredients - talc, starch, stearic acid. When using the product, you should strictly adhere to your doctor’s recommendations and not exceed the recommended course duration. Contraindications:

blood diseases;
intestinal or stomach ulcer;
hypersensitivity;
liver dysfunction.

If used simultaneously with diuretics, the effectiveness of the latter will be reduced by 50-70%. Indications for use:

migraine;
myalgia;
hyperthermia;
pain in joints and muscles;
menstrual pain.

Rules of use:

drink 1-2 tablets at a time;
wait at least 4 hours before your next appointment;
The optimal course duration is 5-7 days.

For menstrual pain, use is prohibited in cases of reduced blood clotting due to the risk of bleeding.

Uralbiopharm is a Russian company engaged in the production of Paracetamol UBF. Available in a dosage of 200 mg for children over 6 years of age and 500 mg for adults. Rules of application:

take 1-2 tablets not on an empty stomach;
no more than four times a day;
Drink plenty of liquid.

Indications for use include pain of various etiologies and elevated body temperature. Contraindications: liver failure. Side effects:

stomach ache;
nausea;
rash and itching;
bleeding;
dizziness.

The drug should not be taken after drinking alcoholic beverages. Combining this product with barbiturates is dangerous. Caffeine makes the effect of paracetamol more pronounced, but it also increases the toxic load on the liver.

Paracetamol Extratab tablets contain additional ascorbic acid at a concentration of 150 mg. The presence of vitamin C increases the effectiveness of the remedy against colds. Rules of use:

drink 1 hour after eating;
do not take with alcohol or hepatotoxic drugs;
Do not take with non-steroidal anti-inflammatory drugs.

Contraindicated for gastric ulcers, intolerance to ingredients, cirrhosis and acute hepatitis.

Paracetamol mg - instructions for use

Depending on the concentration of the main component in the selected drug, the rules for its use differ. Dose calculation formula: body weight multiplied by 10 mg. For example, if a child weighs 12 kg, then the maximum single dose should not exceed 120 mg (one spoon of syrup).

For adults, the maximum permissible dose is 1000 mg. When taking 5 g of paracetamol at once, irreversible consequences for the body may develop.

Effective for the following conditions:

fever, chills;
elevated temperature;
body aches;
menstrual pain;
muscle pain;
joint pain;
migraine;
headache and toothache;
intoxication syndrome in acute respiratory infections and acute respiratory viral infections.

The effectiveness of the drug may be reduced due to incorrect dosage calculations.

The cost of medicine with this trade name several times lower than that imported analogues. Average price in the table.

Paracetamol - analogues - instructions for use, price, reviews

In case of intolerance to the substances that the medicine contains, analogues with other components are selected. The price may vary depending on the manufacturer.

Nimesulide

The drug is used for symptomatic therapy, reduces pain and severe inflammation. Prescribed for:

myalgia;
toothache and headache;
osteoarthritis;
arthralgia;
bursitis;
arthritis.

Take 1 tablet 2 times a day after meals with water.
The drug is not recommended for children under 12 years of age. In addition, the instructions for nimesulide indicate the following contraindications:

hypersensitivity;
bronchial asthma;
alcohol consumption;
flu symptoms;
cardiac and renal failure;
problems with the gastrointestinal tract;
pregnancy and breastfeeding period.

Ibuprofen

Used as an anesthetic for:

postoperative pain;
migraine;
sprains;
lower back pain;
treatment of rheumatoid arthritis;
inflammation of the joint membranes;
ankylosing spondylitis.

The drug should be taken between meals. Adults are prescribed 2-3 tablets 3-4 times a day. The maximum single dose is 4 tablets, the maximum daily dose is 12 tablets.
For children over 12 years of age, the therapeutic dose is 1-2 tablets every 4-6 hours, maximum 5 tablets per day.
Ibuprofen suspension is indicated for children under 12 years of age. The dosage is 5-15 ml 3 times a day.

Paracetamol is given to a child for high fever, headache and toothache. He is considered safe medicine, because even with a threefold overdose it does not cause complications. However, like any medicine, Paracetamol has its own specifics, and must be treated with caution. Before treatment, you should carefully study the instructions for use of Paracetamol, Special attention referring to the calculation of the dosage of tablets for children 1 year and older.

Composition and release forms of the drug

Paracetamol for children is an antipyretic and analgesic with a slight anti-inflammatory effect. Its effectiveness is especially high against viral infections. infectious diseases- It helps little with bacterial diseases.

The therapeutic effect of the drug is based on inhibition of production chemical compounds, which are responsible for the development of inflammatory processes, stimulate an increase in temperature and the appearance pain syndrome. The analgesic and anti-inflammatory effect is achieved due to the effect of the drug on the cells of the central nervous system.

The advantage of the drug over other anti-inflammatory drugs is that it does not have a particular irritating effect on the gastric mucosa. Paracetamol quickly enters the blood, where its highest concentration is achieved in the period from 30 minutes to one and a half hours - depending on the form of the drug. The drug is excreted from the body along with urine after processing in the liver within 4 hours.

Active substance The medicine bears the same name, it is also known as para-acetaminophenol. For children, Paracetamol is available in different forms:

Candles - they contain components that are safest for children. The drug administered rectally is absorbed into the blood more slowly than when swallowed (an hour and a half), which is why the effect occurs later, but it is longer lasting. Doctors may prescribe suppositories for treatment one year old child and even babies from 3 months.
Suspension – excipients include glycerol, sorbitol, flavorings and sucrose. Can be used from 1 month (only as directed by a pediatrician).

Syrup – contains ethanol (96%), excipients, flavorings, dyes. The maximum concentration in the blood is observed half an hour after ingestion. The product is recommended for ages from six months to 12 years.
Tablets or capsules – available in dosages of 200 and 500 mg. Children can be given from 3 years of age (subject to the dosage).
Effervescent tablets for preparing a solution.

IN Lately Paracetamol, produced in the form of sweet syrups and suspensions, has gained particular popularity. By taking these drugs, along with active medicinal ingredients, the baby receives a huge amount of flavorings, sweeteners, and flavoring additives. They can provoke allergic reactions, while allergies to Paracetamol itself are very rare. This means that the ideal option for small children is candles.

Indications for taking Paracetamol tablets (200 and 500 mg)

Paracetamol is effective for:

temperature caused by colds, flu, scarlet fever, measles, vaccinations, etc.;
headaches, including those caused by overexertion;
toothache (caries, teething, etc. (which medications can be given to a child for toothache?), etc.);
pain manifestations not associated with inflammation;
relief of symptoms of colds or flu such as fever, aches;
inflammation of the middle ear (otitis) as a complex therapy.

Paracetamol is used as an antipyretic and pain reliever. When is the drug contraindicated?

Like any medicine, Paracetamol has contraindications. These include:

allergy to the components of the drug;
serious problems with the kidneys and liver, which are involved in processing and removing drugs from the body in urine;
congenital hyperbilirubinemia, or Gilbert's syndrome - increased level bilirubin in the blood (a breakdown product of red blood cells);
some varieties severe infections(eg sepsis);
leukopenia (low white blood cell count);
blood diseases;
deficiency of the enzyme glucose-6-phosphate dehydrogenase;
severe anemia;
taking certain medications (anticonvulsants, barbiturates, rifampicin, etc.);
inflammation of the rectal mucosa (for the use of suppositories).

Instructions for use of tablets

Although Paracetamol is effective in relieving fever and headaches, if you have a serious illness, it will not reduce the temperature.

Dr. Komarovsky calls this medicine a kind of marker: if the fever has decreased after taking it, there is a high probability that the disease is not dangerous - it is a common ARVI. If there is no effect from the drug, the problem is serious, you should urgently call a specialist.

Dosage for children of different ages

Paracetamol tablets are allowed for children over three years of age. For adults, the maximum daily dose is 60 mg/kg. In what dosage is Paracetamol given to children:

norm from 3 to 6 years – 100-200 mg at a time;
from 6 to 12 years – 1-2 tables. (200-400 mg);
adolescents and adults – 500 mg.

Before giving your baby a tablet, you should read the instructions and find out how much paracetamol it contains. If the doctor has prescribed a dose of 100 mg, the 200 mg capsule should be divided into 2 parts, the tablet containing 500 mg should be divided into 5 parts. A slight overdose is not dangerous.

How many times a day can you take the drug?

According to the instructions, children should drink Paracetamol every 4 hours. More frequent use is not recommended because better effect There will be no effect from increasing the dose multiplicity. Paracetamol is absorbed into the blood 30 minutes after entering the stomach and begins to act actively. Maximum concentration and positive effect reached after 2 hours - the temperature begins to decrease.

It is recommended to take the drug every 4 hours; less often - possible, more often - no

As soon as Paracetamol enters the child's blood, the kidneys and liver begin to process it and remove it from the body. After 4 hours, 50% of the substance leaves the body, which leads to a decrease in the effect of the drug. The medicine is completely eliminated after 8 hours. As you recover, the need for frequent use the medication disappears, so the interval can be increased to 5-6 hours.

Duration of treatment

The doctor should tell you how long the course of treatment with Paracetamol will last. At high temperatures, the product can be taken for no more than 3-5 days. Whether it is worth continuing to use the drug and what dose is prescribed per day is determined by the doctor. Irrational use of the drug can cause necrosis of liver cells, kidneys and other problems.

Long-term use of Paracetamol for headaches and toothaches is not advisable, since it can relieve symptoms, but not cure the underlying disease. Diseased teeth need to be treated as soon as possible, as they not only cause pain to the baby, but can also negatively affect the growth of permanent teeth. An unreasonable headache should alert you, as it may indicate serious illnesses and be a reason for further diagnosis.

Side effects

The use of Paracetamol rarely causes side effects. However, their absence cannot be completely ruled out after taking the medicine.

In some cases, the drug may cause gastrointestinal upset

They may appear:

nausea, diarrhea, vomiting, stomach pain, dizziness;
a decrease in the level of leukocytes, erythrocytes, platelets in the blood (extremely rare);
liver pathologies;
allergies;
bronchospasm.

Overdose

The child should not take more than 60 mg of active substance per kg of body weight per day. A dosage of 150 mg/kg is toxic for a baby. This means that if a baby weighs 20 kg, he can die if he takes 3 g of paracetamol during the day.

An overdose causes side effects and signs of intoxication: pale skin, vomiting, sweating, loss of consciousness. If the liver fails, jaundice, hepatic coma, and death are possible. Acute renal failure may occur, which will make itself felt by lower back pain, pancreatitis, arrhythmia, and the appearance of protein and blood in the urine.

Analogues of the drug

Paracetamol is included in many medicines– Coldrex, TeraFlu, Antigrippin, Panadol, Antiflu, Caffetin, etc. Their main differences are excipients, manufacturer, price.

If the medicine does not help, it is replaced with an analogue with another active ingredient. Similar action have drugs based on ibuprofen - Nurofen, Ibufen, etc. In any case, you must remember: even the most harmless medicines You should not prescribe to yourself to avoid unpredictable consequences.

When a child has a fever, the first medicine that parents use to stabilize the condition is paracetamol, and this is not without reason.

The World Health Organization included this drug in the list of the most effective, safe and cost-effective medicines.

Let's take a closer look at the instructions for using Paracetamol tablets for children (200 and 500 mg): recommended dosages for fever, is it possible to give the medicine to a child at all and how much, what to do if the norm is exceeded?

Description and action

Paracetamol is not a new pharmaceutical. It has been used for treatment since 1893. This is one of the safest non-steroidal anti-inflammatory drugs.

The drug has almost no effect on cyclooxygenase, or COX, produced in peripheral organs and tissues. That's why he has less side effects than other NSAIDs.

So, the medicine does not irritate the gastric mucosa, does not lead to disruption of water-mineral metabolism.

At the same time, the drug affects COX, which is produced by the brain, which determines the antipyretic and analgesic properties, the ability to influence inflammatory processes the drug has almost none.

Paracetamol is well absorbed from gastrointestinal tract , therefore tableted dosage forms along with rectal suppositories are most preferred.

The drug acts quickly, and within 30 minutes after administration its highest concentration is observed inside. The effect lasts up to 4 hours.

The lack of effect when using Paracetamol is a reason to immediately seek medical help.

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Release form and composition

The drug is available in tablets of 0.2 g and 0.5 g(200 and 500 mg). This form is recommended for children over 6 years of age due to possible overdose.

Can be used from 2 years of age, although other forms are preferable at this age.

By physical properties It is a pure white or creamy, pinkish crystalline powder that is soluble in alcohol and insoluble in water.

Indications

The drug is used if:

the temperature rises to 38 °C and above (age up to 5 years), up to 38.5 °C (age after 5 years) and lasts for at least 4 hours;
complaints of toothache, headache, muscle pain.

Paracetamol is effective for viral infections(ARVI).

The remedy is also used for chicken pox, measles, flu, rubella, teething, after injuries and burns.

It doesn't help with bacterial infections, complications of ARVI, the effect is short-lived or absent.

Contraindications

The list of contraindications is small In comparison with others medicines. This includes:

individual intolerance;
age up to 2 years;
diseases of the gastrointestinal tract with the formation of ulcers and erosions, stomach bleeding, inflammation, active bleeding;
progressive pathologies of the kidneys, liver, severe forms of failure of these organs;
intolerance acetyl salicylic acid or other NSAIDs;
hyperkalemia ( increased content potassium in the blood).

How much and how to give

Maximum course of treatment is:

up to 6 years - 3 days;
after 6 years - 5 days.

What dose of Paracetamol tablets is needed for children and how to take the medicine correctly?

When prescribing doses, they are guided not by age, but by the weight of the baby. 10–15 mg of active ingredient is prescribed per 1 kg.

Thus, a single dosage of Paracetamol in tablets for children weighing 10 kg is 100–150 mg (0.1–0.15 g), or 1/2–3/4 tablets with a dosage of 200 mg (0.2 g).

Re-appointment should be no earlier than after 4-5 hours. 4–5 doses are allowed per day.

Safe daily dose - up to 60 mg/kg body. This means that a child weighing 10 kg should not be given more than 3 tablets of 200 mg per day.

For teenagers over 12 years of age who weigh more than 40 kg, maximum single dose - 1 g (5 tablets of 0.2 g), daily - 4 g (20 tablets of 0.2 g).

Directions for use, special instructions

The drug is given orally. After eating, 1–2 hours must pass, otherwise absorption will slow down. Drink a lot clean water. If the child is small, then the tablet is crushed into powder.

Paracetamol is an emergency medicine that does not cure, but only eliminates the manifestations of the disease. If the cause of the disease is not eliminated, the fever and pain will return.

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Reception features

The question of what dose of paracetamol to give a child in tablets must be decided after consultation with a doctor. When treating, take into account the following features of admission:

if there is liver disease, the dose is reduced;
when using other drugs simultaneously, you need to make sure that they do not contain paracetamol;
Do not give your child alcohol-containing products, as alcohol enhances the absorption of the medicine.

Overdose

Taking the drug in a single dose of more than 150 mg/kg of the child’s body weight causes severe, and in some cases fatal, liver damage.

Stages of poisoning:

The development of liver failure is indicated:

neuropsychic disorders (feels sleepy, dizzy, speech impaired, hallucinations);
pain in the right side under the ribs;
swelling, abdominal enlargement;
jaundice;
bleeding;
heart rhythm disturbances;
insufficiency of function of other organs.

Death from an overdose occurs within 3–5 days.

In case of overdose, wash the stomach, give the patient activated carbon, call ambulance. The antidote for paracetamol is acetylcysteine.

In case of liver failure, hospitalization is carried out, treatment is symptomatic. In severe cases, a liver transplant may be required.

Children suffer from poisoning more easily than adults, especially those under 6 years of age., due to the characteristics of metabolism. In mild cases, treatment is carried out at home.

How can an overdose occur?

Drug dosage 0.2 mg is safe. So, for a child weighing 10 kg to become poisoned, he needs to take 1.5 g of the drug per day orally, which is 7.5 tablets.

Exceeding the dose occurs for several reasons:

parents in a hurry did not pay attention to the content of the active substance;
other drugs were given at the same time with paracetamol;
increased the frequency of administration;
the baby accidentally took the medicine on his own because it was in an accessible place.

Side effects

Although Paracetamol is well tolerated in most cases, it causes side effects:

IN last years scientists started talking about harm and toxicity.

Studies have shown that children who were frequently prescribed paracetamol at the age of 1–3 years develop allergic diseases by the age of 6–7 years -

Eczema, allergies.

Safety is maintained with infrequent use.

There is also evidence that at long-term use paracetamol more than 1 tablet per day, if the total number taken medication is 1000 or more tablets over a lifetime, the risk of developing severe forms of analgesic nephropathy (kidney disease), which leads to end-stage renal failure, doubles. complete loss kidney function).

Drug interactions

Paracetamol interacts with other drugs, which may affect the safety of therapy.

The following effects may be observed:

promotion harmful effects on the liver, reducing the antipyretic effect of paracetamol - in combination with barbiturates of antiepileptic drugs, rifampicin;
enhancing the effect of coumarin derivatives, salicylic acid, caffeine, codeine;
increase in methemoglobin level - with simultaneous use with phenobarbital.

Do not combine Paracetamol tablets with other means that contain this active ingredient (Parafex, Paravit, Cold-flu, Coldrex and others).

average price

The average price of Paracetamol 0.2 g, 10 tablets is 6 rubles.

Storage conditions and periods

The expiration date is indicated on the packaging(usually 36 months). Store the drug at a temperature no higher than 25 °C, choosing a place inaccessible to minors.

A prescription is not needed to purchase the medicine.

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Reviews

Now you know how to give paracetamol tablets to children, how much medicine to give and what dosage to follow to avoid an overdose. Let's also consider reviews from parents.

Natalya, 28 years old: “Paracetamol helped our son at first. Then they gave me pills, the effect lasted for an hour. Then she gave Nurofen syrup and put suppositories with paracetamol.”

Elena, 30 years old: “Paracetamol has no effect on my baby’s body. I gave the pill, waited an hour and a half, and the effect was zero.”

Yulia, 32 years old: “For bacterial acute respiratory infections, I use Ibuprofen or Paracetamol: the first acts in a quarter of an hour, the second in an hour. For viruses, I give either one or the other drug, both work within an hour. If the temperature persists, we alternate these remedies.”

Among popular means To combat fever and pain in children, there are tablets with paracetamol as the active substance. It is considered the most effective and safe for the child’s body.

Paracetamol-based drugs have three main properties: they relieve fever, inflammation and pain.

Advantages of the drug:

Fights high body temperature during colds, ARVI or flu. It can be given to children aged 2 months, after first reducing the permissible dose.
The decrease in temperature begins quickly and has a long-lasting effect - no further increase is observed.
In some children, high fever may be accompanied by seizures. Paracetamol is also allowed for such unpleasant symptoms.
Reduces or eliminates pain. For example, dental or headache.
Other medications can be given at the same time. Nurofen as active ingredient contains ibuprofen, so alternating them is allowed.

It should be taken into account that paracetamol eliminates only the symptoms of the disease, but is not intended for its treatment. The main cause of pain or fever should be identified and children treated with other medications.

Dosage of the drug

Paracetamol comes in three main forms: suppositories, tablets and syrups. You can buy a product at the pharmacy where this active ingredient is in pure form- Panadol for example. Panadol tablets, in addition to the active substance, contain sodium bicarbonate, which creates an alkaline environment in the body. Thanks to this, Panadol works faster.

Candles

They are inserted rectally - into the child's anus. Before the procedure, you must first wash your hands. Place the child, turn him on his side, bend his legs and press them to his tummy. Slowly and carefully introduce the suppository. The active substance is absorbed by the intestinal walls and has a rapid effect at high temperatures. For children under three months, the dosage is selected only by a doctor..

At the pharmacy you can find the following dosage of the drug:

from 3 months to a year, 0.08 gram suppositories are prescribed;
from 1 year to 3 years – 0.17 grams;
from 3 years to 6 – 0.33 grams;
starting from 6 years and older, two suppositories of 0.33 grams are prescribed.

You should not use more than 4 suppositories per day.

Pills

They are allowed for children starting from two years old. The child is given medicine, previously crushed and diluted in water. Children's paracetamol tablets are available in a dosage of 200 mg:

from 2 to 6 years, 1/2 tablet is prescribed at a time;
from 7 to 12 years, one full tablet is allowed;
Children over 12 years of age are allowed to take two tablets at a time.

In some cases, this form can also be taken by children under one year of age. Especially when it comes to a very high temperature with the appearance of seizures. In such cases, the use of the medicine is allowed in the following dosage:

from birth to 3 months, the dosage is 10 mg per kilogram;
from 3 months to a year, the maximum daily dose is 120 mg;
from one year to 2 years, the maximum daily dose is 150 mg.

Syrup

This dosage form has a liquid consistency and a pleasant taste, so children swallow it without difficulty. Syrup can be given as early as two months. Sometimes doctors, taking into account the child’s condition at the time of illness, can prescribe syrup in the first weeks of life.

The kit includes a convenient dispenser syringe or measuring spoon, with which the exact amount of suspension is measured. The drug should not be diluted with water; it is better to give the child something to drink after taking it.

The exact dosage is drawn according to the divisions on the syringe:

from birth to 6 months, the dosage is calculated by the attending physician;
from 6 months to one year, the maximum dosage is 5 mg, the minimum is 2.5 mg;
up to 3 years, the dosage is 5 – 7.5 mg;
from 3 to 6 years – the maximum dosage is 10 mg;
from 7 to 12 years – about 15 mg.

The medicine begins to act within 30 minutes after administration. At high temperatures, the syrup is given for no more than three days. As a painkiller, the drug can be taken for up to five days.

An analogue of the drug Paracetamol is Panadol. It is approved for children aged 3 months and older. Panadol Baby can be used to relieve fever, inflammation and pain. Can also be used after vaccinations.

Features of application

Before giving medicine to a child, you should consult your pediatrician. He will appoint correct dosage and will tell you about the rules of admission.

The dosage of the drug depends on the age and weight of the child.
Paracetamol tablets should be given to relieve fever at intervals of 6 hours. No more than four times a day.
In children under the age of one year, the temperature should be reduced if it rises above 38 degrees.
Paracetamol should not be given to infants for more than three days. Their internal organs are not yet fully formed, which creates an extra load on the liver.
This antipyretic should not be given for prophylaxis.
For a small child, the tablet must first be dissolved in water.
You should not use a tablet intended for adults - it is impossible to accurately determine the dosage.
Nurofen is more irritating to the stomach than Panadol. Therefore, it is better to stop at the last drug.

Tips for taking medications that contain paracetamol

Exist various shapes release of this active ingredient. It can be in candles, syrups or in the form of a suspension. They are best suited for children under one year old.
To reduce the harmful effects on the liver, the medicine should be given after meals.
A dosage of 150 mg per kilogram of weight is dangerous for a child’s body.
An overdose can be recognized by the following symptoms: the skin becomes pale, nausea and vomiting appear. In this case, you need to urgently consult a doctor.

Sometimes, when the temperature is high and falls heavily, children are prescribed two drugs at the same time: Nurofen and Paracetamol. These drugs are given at intervals. Nurofen acts quickly and the effect is longer lasting.

You can combine Nurofen with paracetamol at the same time. In this case, half the dose is taken from each drug.

Contraindications

Overdose of the drug and frequent use, which negatively affects the functioning of the liver, are not allowed. Nausea and vomiting appear.
Individual intolerance to the components of the drug. Allergic reactions may occur.
For children under two years of age, paracetamol should be given with caution - the drug can cause asthma.
Do not give two paracetamol-based medications at the same time. This will lead to poisoning of the body. Can be given with other antipyretics, for example, Nurofen.
An overdose can occur if the interval between doses of the medication is not observed. It's better to combine drug treatment with folk remedies.
The drug is contraindicated for diseases such as anemia, hyperbilirubinemia, and disorders of the kidneys and liver.

If at least one symptom appears, then it should be replaced this medicine to another. Nurofen is less likely to cause allergies and causes less harm internal organs. Just like paracetamol, Nurofen is available in the form of suppositories, tablets and syrup.

There are many medications in pharmacies that contain paracetamol. Panadol is available in tablets, suppositories and syrups. Panadol Baby is specially produced for the little ones

Do not forget that all medications must be kept away from children. It is better to store medications for adults separately from children, so that during the period of illness the child does not mix up medications due to increased anxiety.

Before giving paracetamol to a child, you should consult your doctor. It is he who will tell you which dosage form is best to choose and whether it is worth combining it with other antipyretics. Calculate the exact permitted dosage. Only by following the rules and recommendations can you reduce side effects and overdose.

During development colds The first sign in children is fever. If pediatricians prohibit giving children antipyretics at elevated temperatures, then if the thermometer readings are above 39 degrees, you should definitely resort to medication. One of the most effective ways Reducing high fever is a medicine called Paracetamol. Is it possible to give children Paracetamol in tablets, at what age should it be used, as well as the specific dosage of the drug, we will find out further.

Dosage of Paracetamol tablets

Paracetamol for fever is available in three forms: tablets, syrup and rectal suppositories. All forms of the drug are intended to reduce high fever. Paracetamol in certain dosage forms should be given to a child depending on his age.

The main advantage of the drug in tablet form is its low cost, especially when compared with syrups. Many parents resort to medication in tablets only when the child turns 5 years old. It is at this age that a baby can swallow a pill without it getting stuck in the throat. Some parents are in no hurry to resort to using the drug in tablets, and give it from the age of 6.

The instructions for use indicate that children can be given the drug in tablet form at 2 years of age and older. However, it is important to note that at 2-3 years of age it is preferable to give syrup to children, and before 2 years of age it is best to use rectal suppositories. It is possible for young children to take Paracetamol in tablet form if they have a fever, but the tablet should initially be crushed and then given to drink with sweetened water.

It is important to know! At high temperatures, children can be given Paracetamol no more than 4 times a day. The break between subsequent doses should be 4-6 hours. The duration of therapy should not be more than 3 days.

How to give Paracetamol tablets to children depends on their age and weight. Paracetamol for children with fever should be calculated based on the following dosage: per 1 kg of baby’s body weight, 10 mg of the drug is required. For a baby whose weight is 10 kg, 100 mg of the drug will be required.

Interesting to know! The drug can bring down a child’s temperature approximately 25-30 minutes after administration.

Dosage of Paracetamol 200 mg in tablet form

We have already found out whether Paracetamol can be given to children. It is only worth noting that if a child of 5-6 years old cannot swallow the tablet whole, it should be divided into parts or crushed into powder. It is not recommended to give the drug to infants in tablet form, so it is better to resort to rectal suppositories.

The drug Paracetamol 200 mg is very popular. The tablets are quickly absorbed by the body, so within 30 minutes a positive effect from its use occurs. In addition, the tablets do not contain flavorings or dyes, which can harm the baby if taken orally. You can not only bring down the temperature with the drug, but also reduce pain symptoms for toothaches, headaches, neuralgia and osteochondrosis. Let’s find out in more detail how to lower the temperature with the help of the medicine in question.

It is not recommended to give antipyretic tablets to children under two or three years of age. Moreover, if the doctor has prescribed the use of the drug for the baby in this form, then you can resort to such treatment.
Children under the age of five or six years can be given the medicine in tablet form, but only at a dosage of 100 mg. Paracetamol can be given to a child at this age no more than 2 times a day.
Children under 12 years of age are given the drug at a dosage of 200 mg. The dosage of Paracetamol depends primarily on weight, so before giving the medicine to your baby, you need to read the instructions.
Older children from 12 years of age can be given Paracetamol at a dosage of 500 mg.

The instructions indicate that children under 12 years of age can be given tablets with a dosage of 500 mg, but the dose must be calculated correctly. It is also important to note the fact that before giving medicine at a temperature of 38 and above, you should consult a specialist. Your local or attending physician will tell you how to take it, how much of the drug you need, and how often you can take it.

It is important to know! You need to lower your baby’s temperature if the thermometer shows above 39 degrees. An adult can begin to reduce the fever if the mark exceeds 39-39.5 degrees.

Can children take medicine in tablets?

Doctors say that children can take pills if certain conditions are met.

If the thermometer reading is above 38.5-39 degrees. For children under 3-4 years old, it is necessary to reduce the fever above 38-38.5 degrees.
There is no need to rush to bring the fever down below 38. If the thermometer readings are above 38, you should initially try using a traditional method, for example, wiping with a vinegar solution. If the fever continues to rise or lasts four hours or more after the parents have tried all methods to reduce it, then this medicine can be given.
Is it possible for a child to take Paracetamol, and in what dosage should it be used for high fever, toothache and weakness. It can not only be given, but it is also necessary. If the drug does not bring down the fever, but at the same time painful sensations If teething has decreased, you should consult a specialist or replace the medication with Ibuprofen.

Paracetamol is excellent remedy in the fight against high fever in children of different ages. With age, the form of the drug can be changed, and the name of the drug can remain the same, but on one condition that the drug gives a positive effect.

Is it dangerous to overdose on a medicine?

The instructions indicate that in case of an overdose of the drug you should consult a doctor. We found out how to give Paracetamol to children, but why is an overdose so dangerous? of this product? In fact, Paracetamol is one of the safest antipyretic drugs. In case of a slight overdose, this will not affect the baby’s health in any way, especially if the medicine is used in a single dosage.

It is important to know! Before using Paracetamol in tablets for children with fever, you should familiarize yourself with the dosage of the medicine, and then select it according to the baby’s weight.

Depending on the excess amount of the drug, the baby may experience side symptoms from an overdose. Excessive doses of the drug cause negative effects on organs such as the kidneys and liver. Most often, with a regular overdose of the drug, liver damage develops, as well as hepatic comas.

Symptoms of a Paracetamol overdose include:

nausea and vomiting;
abdominal pain;
problems with stool;
the occurrence of drowsiness.

Most dangerous sign overdose is intoxication. In this case, you definitely need to go to the hospital for help. Therefore, the question of whether a child can take Paracetamol should be answered in such a way that the medicine is not only allowed, but also necessary if necessary. In order not to make a mistake with the dosage, you must carefully read the instructions or consult a specialist.

At what months can you give your baby goat milk? At what age can you give your baby coffee with milk?

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Owner/Registrar

MEDISORB, JSC

International Classification of Diseases (ICD-10)

K08.8 Other specified changes in the teeth and their supporting apparatus M79.1 Myalgia M79.2 Neuralgia and neuritis, unspecified N94.4 Primary dysmenorrhea N94.5 Secondary dysmenorrhea R50 Fever of unknown origin R51 Headache R52.0 Acute pain R52.2 Other constant pain

Pharmacological group

Analgesic-antipyretic

pharmachologic effect

Analgesic-antipyretic. It has analgesic, antipyretic and weak anti-inflammatory effects. The mechanism of action is associated with inhibition of prostaglandin synthesis, with a predominant effect on the thermoregulation center in the hypothalamus.

Pharmacokinetics

After oral administration, paracetamol is rapidly absorbed from the gastrointestinal tract, mainly in small intestine, mainly by passive transport. After a single dose of 500 mg, Cmax in blood plasma is reached after 10-60 minutes and is about 6 μg/ml, then gradually decreases and after 6 hours it is 11-12 μg/ml.

Widely distributed in tissues and mainly in body fluids, with the exception of adipose tissue and cerebrospinal fluid.

Protein binding is less than 10% and increases slightly with overdose. Sulfate and glucuronide metabolites do not bind to plasma proteins even at relatively high concentrations.

Paracetamol is metabolized primarily in the liver by conjugation with glucuronide, conjugation with sulfate and oxidation with the participation of mixed liver oxidases and cytochrome P450.

The negatively acting hydroxylated metabolite N-acetyl-p-benzoquinoneimine, which is formed in very small quantities in the liver and kidneys by mixed oxidases and is usually detoxified by binding to glutathione, can escalate with paracetamol overdose and cause tissue damage.

In adults, most paracetamol is bound to glucuronic acid and to a lesser extent - with sulfuric acid. These conjugated metabolites do not have biological activity. In premature babies, newborns and in the first year of life, the sulfate metabolite predominates.

T1/2 is 1-3 hours. In patients with liver cirrhosis, T1/2 is slightly longer. The renal clearance of paracetamol is 5%.

It is excreted in the urine mainly in the form of glucuronide and sulfate conjugates. Less than 5% is excreted as unchanged paracetamol.

Pain syndrome of mild to moderate intensity of various origins(including headache, migraine, toothache, neuralgia, myalgia, algodismenorrhea; pain from injuries, burns). Fever in infectious and inflammatory diseases.

Chronic alcoholism, increased sensitivity to paracetamol.

From the digestive system: rarely - dyspeptic symptoms, with prolonged use in high doses- hepatotoxic effect.

From the hematopoietic system: rarely - thrombocytopenia, leukopenia, pancytopenia, neutropenia, agranulocytosis.

Allergic reactions: rarely - skin rash, itching, urticaria.

special instructions

Use with caution in patients with impaired liver and kidney function, with benign hyperbilirubinemia, as well as in elderly patients.

With long-term use of paracetamol, it is necessary to monitor the peripheral blood picture and functional state liver.

It is used to treat premenstrual tension syndrome in combination with pamabrom (a diuretic, a xanthine derivative) and mepiramine (a histamine H1 receptor blocker).

For renal failure

Use with caution in patients with impaired renal function.

In case of liver dysfunction

Use with caution in patients with impaired liver function.

Elderly

Use with caution in elderly patients.

Use during pregnancy and breastfeeding

Paracetamol penetrates the placental barrier. To date, there have been no negative effects of paracetamol on the fetus in humans.

Paracetamol is excreted in breast milk: the content in milk is 0.04-0.23% of the dose taken by the mother.

If necessary, use paracetamol during pregnancy and lactation ( breastfeeding) the expected benefit of therapy for the mother and the potential risk to the fetus or child should be carefully weighed.

IN experimental studies The embryotoxic, teratogenic and mutagenic effects of paracetamol have not been established.

Drug interactions

When used simultaneously with inducers of microsomal liver enzymes and drugs with hepatotoxic effects, there is a risk of increasing the hepatotoxic effect of paracetamol.

When used simultaneously with anticoagulants, a slight or moderate increase in prothrombin time is possible.

When used simultaneously with anticholinergic drugs, the absorption of paracetamol may be reduced.

When used simultaneously with oral contraceptives, the elimination of paracetamol from the body is accelerated and its analgesic effect may be reduced.

When used simultaneously with uricosuric drugs, their effectiveness decreases.

With simultaneous use of activated carbon, the bioavailability of paracetamol decreases.

When used simultaneously with diazepam, the excretion of diazepam may be reduced.

There are reports of the possibility of enhancing the myelosuppressive effect of zidovudine when used simultaneously with paracetamol. A case of severe toxic damage liver.

Cases of toxic effects of paracetamol have been described when used simultaneously with isoniazid.

When used simultaneously with carbamazepine, phenytoin, phenobarbital, primidone, the effectiveness of paracetamol decreases, which is due to an increase in its metabolism (glucuronidation and oxidation processes) and excretion from the body. Cases of hepatotoxicity have been described with the simultaneous use of paracetamol and phenobarbital.

When using cholestyramine for a period of less than 1 hour after taking paracetamol, the absorption of the latter may be reduced.

When used simultaneously with lamotrigine, the excretion of lamotrigine from the body moderately increases.

When used simultaneously with metoclopramide, it is possible to increase the absorption of paracetamol and increase its concentration in the blood plasma.

When used simultaneously with probenecid, the clearance of paracetamol may be reduced; with rifampicin, sulfinpyrazone - it is possible to increase the clearance of paracetamol due to an increase in its metabolism in the liver.

When used simultaneously with ethinyl estradiol, the absorption of paracetamol from the intestine increases.

Orally or rectally in adults and adolescents weighing more than 60 kg, use a single dose of 500 mg, frequency of administration - up to 4 times a day. The maximum duration of treatment is 5-7 days.

Maximum doses: one-time - 1 g, daily - 4 g.

Single oral doses for children aged 6-12 years - 250-500 mg, 1-5 years - 120-250 mg, from 3 months to 1 year - 60-120 mg, up to 3 months - 10 mg/kg. Single doses at rectal use in children aged 6-12 years - 250-500 mg, 1-5 years - 125-250 mg.

Frequency of application - 4 times/day with an interval of at least 4 hours. Maximum duration of treatment - 3 days.

Maximum dose: 4 single doses per day.

Manufacturer: OJSC "Borisov Plant" medical supplies" Republic of Belarus

PBX code: N02BE01

Farm group:

Release form: Solid dosage forms. Pills.

General characteristics. Compound:

Active ingredient: 200 mg or 500 mg of paracetamol in each tablet.

Excipients: povidone, croscarmellose sodium, stearic acid, potato starch.

Pharmacological properties:

Pharmacodynamics. Paracetamol has an analgesic and antipyretic effect.

The mechanism of action is associated with inhibition of the activity of cyclooxygenase types I and II (COX-I and COX-II). As a result, the reactions of the arachidonic cascade of eicosanoid synthesis are blocked and the formation of prostaglandins PgE2, PgF2a, and their endoperoxides is disrupted.

Paracetamol has an analgesic effect and increases the threshold of excitability of the pain centers of the thalamus. At the same time, it reduces the activity of the thermosetting center of the hypothalamus, the influence of endogenous pyrogens on it, and enhances heat transfer. It is effective for pain of mild and moderate intensity, fever of infectious origin. Used as an analgesic and antipyretic, primarily in persons with contraindications to taking other non-steroidal anti-inflammatory drugs: patients bronchial asthma, peptic ulcer, children with viral infections.

The drug does not have an anti-inflammatory effect and does not have an antiplatelet effect. This is due to its inactivation at the site of inflammation under the influence of oxygen peroxide and free radicals, which are formed in abundance at the site of inflammation. Thus, in the area of inflammation, cyclooxygenase remains protected from the action of paracetamol and the anti-inflammatory effect does not develop.

Paracetamol can be used in the treatment of patients with disorders of the blood coagulation system (hemorrhagic diathesis).

Pharmacokinetics. After oral administration, it is rapidly absorbed mainly in the small intestine, mainly by passive transport. After a single dose of 500 mg, the maximum plasma concentration is reached after 0.5 - 2 hours and is about 16 mcg / ml, after which it gradually decreases to a level of 11 - 12 mcg / ml 6 hours after administration. With repeated administration of the drug, its pharmacokinetics do not change. Cumulation of the drug is not observed.

In plasma, about 10 - 15% of the drug is in a protein-bound state. Penetrates well through histohematic barriers, evenly distributed throughout organs and tissues (with the exception of adipose tissue). Passes through the blood-brain barrier, the placenta, and enters breast milk (less than 1% of the dose taken).

The volume of distribution (Vd) is 0.95 l/kg.

Metabolized in the liver in three independent ways: 1) conjugation with glucuronic acid (about 50%) with the formation of inactive metabolites; 2) conjugation with sulfates (about 30%) with the formation of inactive metabolites; 3) hydroxylation by the cytochrome P450 system with the formation of the active intermediate metabolite N-acetyl-benzoiminoquinone (N-ABI about 17%). N-ABI subsequently binds to glutathione and undergoes inactivation to form paracetamol mercaptopurate with the participation of mercaptopurine and cysteine. With a lack of glutathione, N-ABI can block the enzyme systems of hepatocytes and cause them. In premature babies, newborns and children under 10 years of age, the main metabolite of paracetamol is paracetamol sulfate; in children over 12 years of age, the main metabolite of paracetamol is glucuronide.

The half-life of paracetamol (T1/2) is 2 - 3 hours. In children it is slightly less, in newborns, the elderly and patients with impaired liver function it is slightly longer. Excreted by the kidneys in the urine, 30.5 - 58.5% in the form of glucuronide, 17.5 - 33.9% in the form of sulfate, 4.5 - 6.1% in the form of paracetamol mercaptopurate, 0.4 - 5 .9% - in the form of paracetamol-cysteine and 3.5 - 4.5% - unchanged. Excreted in the form of metabolites in the urine.

Indications for use:

For mild treatment and moderate pain, including headache, toothache, pain due to osteoarthritis, febrile syndrome for acute infectious, infectious-inflammatory diseases.

Important! Get to know the treatment

Directions for use and dosage:

Use internally, preferably between meals.

Adults, elderly people and adolescents over 12 years of age: 1000 mg (2.5-5 tablets with a dosage of 200 mg, 1-2 tablets with a dosage of 500 mg) every 4 hours, maximum dose up to 4000 mg within 24 hours.

Children 6-12 years: 200 mg - 500 mg (1 tablet with a dosage of 200 mg, ½ to 1 tablet with a dosage of 500 mg) every 4 hours, maximum dose up to 2000 mg within 24 hours. In children under 6 years of age, the use of tablets is not recommended.

Features of application:

Pregnancy and lactation. The use of paracetamol during pregnancy and lactation is contraindicated. If it is necessary to use paracetamol during lactation, the child should be weaned from the breast for the entire period of treatment.

The tablets are not intended for use in children under 6 years of age.

Long-term use of paracetamol. If it is necessary to regularly use paracetamol for more than 5 days, peripheral blood patterns and liver function should be monitored weekly.

Effect on laboratory parameters. During treatment with paracetamol, it is possible to increase the level of glucose in the blood plasma and distort the results of determining the glycemic profile.

Influence on the ability to drive vehicles and operate machinery. Taking paracetamol does not affect the ability to drive vehicles or use other mechanisms during the period of use of the drug.

Side effects:

Nephrotoxic effect in the form of aseptic, papillary necrosis;

Demotion blood pressure, .

Interaction with other drugs:

When used simultaneously with cytochrome P450 inducers (phenytoin, alcohol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants, combined oral contraceptives) the production of the hydroxylated toxic metabolite N-ABI and the risk of hepatotoxic action of paracetamol increases.

Alcohol enhances the toxic effect of paracetamol on the pancreas.

When used simultaneously with cytochrome P450 inhibitors (cimetidine, omeprazole, macrolide antibiotics), the risk of hepatotoxic action of paracetamol is reduced.

Paracetamol enhances the effect of drugs that depress the central nervous system nervous system, alcohol. Potentiates the hematotoxic effect of chloramphenicol. Weakens the effectiveness of uricosuric drugs (sulfinpyrazone).

When used simultaneously with myotropic antispasmodics (drota-verine, papaverine, pitofenone) and m-anticholinergic blockers (fenpiverinium bromide, platyphylline, atropine), cholestyramine, a slowdown in the absorption of paracetamol is observed due to slower gastric emptying.

When used simultaneously with prokinetic agents (metoclopramide), erythromycin, acceleration of paracetamol absorption is observed due to accelerated gastric emptying.

Barbiturates weaken the antipyretic effect of paracetamol.

When taken simultaneously with cholestyramine, cimetidine, omeprazole, the rate of absorption of paracetamol decreases. Paracetamol can be used no earlier than one hour after using cholesterol, no earlier than two hours after using cimetidine, omeprazole.

The anticoagulant effect of warfarin and other coumarins may be enhanced by long-term regular use of paracetamol in patients at increased risk of bleeding. Single doses do not have a significant anticoagulant effect.

Contraindications:

Glucose-6-phosphate dehydrogenase deficiency;

Hypersensitivity to paracetamol;

Pregnancy and lactation;

Children under 6 years old.

Overdose:

Occurs when taking paracetamol in a dose of more than 10 g/day (or more than 140 mg/kg/day in children). In patients with alcoholism and hepatitis, the toxic effect of paracetamol can occur even when used at a dose of 2.5-4.0 g/day.

Treatment: includes withdrawal of the drug, with activated charcoal and the administration of saline laxatives to prevent absorption of the drug in the stomach and intestines. Intravenous administration of glucose is started (5 - 10% solution 200 - 400 ml).

A specific antidote is introduced - N-acetylcysteine (restores glutathione reserves and eliminates its deficiency, while the toxic metabolite of paracetamol is neutralized). A 20% solution of N-acetylcysteine is used intravenously and orally: the first dose is 140 mg/kg (0.7 ml/kg), then 70 mg/kg (0.35 ml/kg). A total of 17 doses are administered. The most effective treatment is started in the first 10 hours after the development of intoxication. If more than 36 hours have passed since intoxication, treatment is ineffective. When the prothrombin index increases by more than 1.5, vitamin K1 (phytomenadione) 1 - 10 mg is used; if the prothrombin index increases to more than 3.0, it is necessary to begin infusion of native plasma or a concentrate of coagulation factors (1 - 2 units).

When treating intoxication, it is contraindicated. Cannot be used antihistamines and glucocorticosteroids.

Storage conditions:

In a place protected from light and moisture, at a temperature not exceeding 25 ºС. Keep out of the reach of children. Shelf life - 3 years. Do not use after expiration date.

Vacation conditions:

On prescription

Package:

Tablets 200 mg: in blister packs No. 10 × 2, No. 10 × 500; in blister-free packaging No. 10 × 1, No. 10 × 800.

Tablets 500 mg: in blister packs No. 10 × 2, No. 10 × 5, No. 10 × 300; in blister-free packaging No. 10 × 1, No. 10 × 390.

In childhood, situations often arise when a child needs to take medications; fever is a particularly common pathology. For fever, doctors usually prescribe paracetamol 200 or products that contain it. In this article we will talk about the rules for taking this drug and its dosage for children.

As the instructions for use for children state about the drug paracetamol 200 milligrams, its composition has a number of contraindications. The drug should not be taken if the baby has hypersensitivity to the components of the drug; in such cases, the drug should be replaced alternative methods.

Also, the instructions for the use of paracetamol 200 tablets prohibit the use of the product for treating children under three years of age. At this age, as a rule, the tablet is divided into several parts.

Release form and composition

Paracetamol 200 mg tablets, according to the instructions, are an analgesic and antipyretic with a mild anti-inflammatory effect. They are especially effective for fever caused by infectious and viral pathologies.

The therapeutic effect of the drug is based on its effect on pain centers, resulting in an increase in the threshold for pain perception. The main advantage of the medicine is that it does not have a harmful effect on the mucous membranes of the gastrointestinal tract. The medication quickly enters the bloodstream, does not accumulate and is completely eliminated from the body within four hours.

Active ingredient The drug is para-acetaminophen, also known as paracetamol. One of the advantages of the drug is its many release forms, let’s consider them:

Suppositories - used to treat infants starting from three months. The advantage of this form of release is that rectal suppositories are absorbed into the blood more slowly, so the effect lasts longer.
Syrup contains sugar and is therefore contraindicated in patients with diabetes. Recommended for use from twelve years of age.
– contains glycerol, sucrose, flavorings, sorbitol. Prescribed to newborns starting from one month.
Capsules and tablets are recommended for children from three years of age. Pharmacies sell 500 and 200 milligrams.

Note! When treating children of different ages, suspensions and syrups are especially popular, but they contain a large number of flavorings and aromas, which can provoke allergies in a small patient. In this case, it is most preferable to use rectal suppositories, which are safer and more gentle.

This drug is a non-steroidal analgesic that does not affect the production of COX and has fewer contraindications than other drugs in the NSAID group.

In addition, the medication does not irritate the mucous membranes of the gastrointestinal tract and does not disturb the water-salt balance in the body. At the same time, paracetamol has a beneficial effect on COX, which is responsible for its analgesic and antipyretic properties.

The medicine is well absorbed from the stomach, so in tablet form it is more effective at high temperatures than rectal suppositories. The medication acts quickly enough; after half an hour, its highest concentration is observed in the body. The effect lasts about four hours.

Description and properties of the drug

Paracetamol has a powerful analgesic and antipyretic effect. Its anti-inflammatory properties are weakly expressed, so the drug is used to treat various types of inflammation in combination with other drugs of the NSAID group.

When the drug is indicated, what information does the instructions for using paracetamol 200 mg tablets for children contain? We will talk about this in the following paragraphs.

Indications for use

This drug is prescribed in the following cases:

Fever caused by infectious and viral diseases;
Moderate and mild pain;
Migraine;
Arthralgia;
Toothache;
Neuralgia;
Muscle pain;
Pain caused by injuries and damage skin;
Myalgia;
Pain syndrome during teething;
Algodismenorrhea.

Contraindications

Among the contraindications of the drug, the following conditions are noted:

Individual intolerance to components;
Infancy up to one month;
Liver and kidney failure;
Gilbert's syndrome;
Pregnancy and;
Glucose deficiency;
Cancerous tumors;
Viral hepatitis;
Old age;
Chronic alcoholism;
Diabetes(syrup).

Paracetamol 200 mg, what dosages are allowed for children? This question interests many mothers. The medicine in tablets should be taken with plenty of liquid an hour after meals. If you don't comply this rule, then paracetamol 200 mg for children at the indicated dosage will not have the desired effect.

At a temperature of 38 degrees, paracetamol 200 mg in tablets is given to children in the following dosages:

from 3 to 6 months – 350 milligrams;
from 6 months to a year – 500 milligrams;
from 1 year to 3 years – 750 milligrams;
from 3 years to 6 years – 1 gram;
from 6 years to 9 years – 1.5 grams;
from 9 years to 12 years – 2 grams.

For children under three months of age, the maximum permissible dosage is determined by the doctor depending on weight, the calculation is made in the ratio of 1 mg/kg.

The dosage of paracetamol 200 mg suspension for children is as follows:

from 3 months to a year – 5 milliliters;
from 3 years to 6 years – 10 milliliters;
from 6 to 12 years – 20 milliliters.

Suppositories:

from 3 to 6 months – 80 milligrams once a day;
from 6 months to a year – 80 milligrams 2 times a day;
from 1 year to 3 years – 80 milligrams 3 per day;
from 3 years to 6 years – 150 milligrams 2 times a day;
from 6 years to 9 years – 150 milligrams 3 times a day;
from 9 years to 12 years – 200 milligrams.

The frequency of treatment for fever, regardless of the form of release, is three days with a dosage interval of four hours.

Use during pregnancy and breastfeeding

During pregnancy and breastfeeding, the drug is rarely used and only as prescribed by a doctor. In the first case, any medications are generally contraindicated in order to avoid harm to the health of the unborn baby. In the second case, the whole point is that the drug accumulates in breast milk in small quantities.

Side effects

When taking the medicine in the dosages indicated in the instructions, as a rule, there are no side effects. Side effects may occur with hypersensitivity to the components and impaired liver and kidney function.

In such cases, the patient notes the appearance of the following symptoms:

allergies, rash, itching, urticaria;
vomiting and nausea;
dizziness;
loss of orientation in space;
pain in the stomach;
insomnia;
exacerbation of liver and kidney pathologies;
pain in the heart area;
indigestion.

special instructions

When using medicine to treat children, the following rules must be observed:

Tablets are given no more than four times a day.
The dose of the medicine depends on the body weight and age of the baby.
Use the product at temperatures above 38 degrees.
The duration of treatment should not exceed three days.
There is no need to use the medicine for prophylactic purposes.
Do not use the drug in combination with other medications with a similar active substance.

Interaction with other drugs

Paracetamol interacts with various medications. Consider this impact on their medicinal properties:

Uricosuric – reduces therapeutic properties;
Anticoagulants – increases their toxicity;
Ethanol - the combination provokes the development of acute pancreatin;
Barbiturates – reduces healing effect;
Cimetidine – increases the risk of intoxication of the body;
NSAIDs – the combination promotes the development of necrosis;
Salicylates - may cause cancer Bladder and how much;
Myelotoxic substances – increases the risk of hematotoxicity;
Diflunisal - increases the accumulation of the substance in the blood.

Overdose

In case of non-compliance permissible dosages possible development of intoxication of the body in acute or chronic form. For a child, a single dosage of more than 150 milligrams is dangerous, which can also lead to fatal liver damage. Acute form occurs two hours after administration. Chronic overdose develops within 24 hours after application.

Overdose is accompanied the following symptoms:

Vomit;
Nausea;
Diarrhea;
Fainting;
Change in skin color;
Disorders of the liver and kidneys.

When the first symptoms appear, the patient needs to call an ambulance and empty his stomach. The stomach is washed with a weak solution of potassium permanganate until the emerging liquid becomes clear.

If renal or liver failure develops, the patient must be hospitalized. In some cases, a liver transplant may be needed. A child tolerates intoxication much easier than an adult, this is due to the peculiarities of metabolism.

If renal or liver failure develops, the patient must be hospitalized. In some cases, a liver transplant may be needed.

Storage conditions and expiration dates

The medicine should be stored in a cool, dry place at an air temperature of no more than 25 degrees and normal humidity. The drug should be stored in a place where children do not have access. The shelf life of the medicine is three years from the date of manufacture. Do not use the medicine after the expiration date.

Paracetamol is effective drug to normalize the body and eliminate pain. It is often used. However, paracetamol has a number of contraindications that contribute to the development severe complications. When treating with this substance, it is also necessary to observe the permissible doses and frequency of treatment, otherwise there is a high risk of severe intoxication of the body. There is no need to use paracetamol without a doctor's prescription and for preventive purposes.