Prozerin instructions for use intramuscular injections. Prozerin - official* instructions for use

To date, diseases nervous system are not uncommon. And there can be many reasons for this phenomenon. For example, poor lifestyle, poor environment, heredity, overwork and others. "Prozerin" in ampoules, instructions for use characterize it as incredible effective remedy, intended for the treatment of certain ailments of the nervous system. In this article we will look at all the features of this medicine, and we’ll also figure out how to use it correctly.

Release form and composition

The instructions for use describe the drug "Prozerin" in ampoules as a solution intended for the injection method of treatment. The solution itself is absolutely transparent and colorless and does not have a specific odor. The main active substance of this medication is proserin. In this case, each milliliter of solution will contain 0.5 mg active substance. In addition, the drug also contains an auxiliary component.

This includes sterile water. Each ampoule, made of glass, contains 10 ml of medicine. The drug “Proserin” in ampoules, instructions for use of which are included in each original packaging, can be purchased either individually or as a whole box containing ten glass tubes.

Pharmacokinetic properties

At correct use such medicinal substance, like prozerin, the enzyme acetylcholinesterase will be blocked in the human body. Due to this, the following effects will be observed:

the drug has an active effect on all muscles of the human body;
at the same time, increased work of the salivary, sweat, sebaceous and other glands is observed;
the pressure inside the eye will begin to decrease, and the pupil itself will narrow;
The work of the sphincter and intestinal walls will also increase.

The drug is usually administered intravenously, intramuscularly or subcutaneously. Your doctor will determine which method is right for you. The active component of the drug can accumulate very quickly in blood cells and spread throughout all tissues of the human body. At the same time, the drug “Proserin” in ampoules, the instructions for use of which are described in this article, does not affect the central nervous system, which makes the medication as safe as possible. But the metabolic processes of prozerin occur in the liver, after which the breakdown products are almost completely eliminated by the urinary system.

“Proserin” in ampoules, instructions for use and analogues of which are described in this article, can be used to treat certain diseases of the nervous system. Let's take a closer look at the exact cases in which doctors prescribe this medicine to their patients:

Very often, experts recommend their patients to use Proserin injections when their muscles are significantly weakened. In this case, the etymology of the origin of the disease does not matter.
The remedy also performed very well during the recovery period after suffering a brain injury, stroke, or when muscle motor function was impaired as a result of other diseases of the nervous system.
The product can cope with atrophy optic nerve, and also with inflammatory processes in him.
The drug perfectly improves muscle tone Bladder and intestines.
Very often, doctors recommend using Proserin injections during the recovery period after undergoing treatment with certain types of medications.

“Proserin” in ampoules, instructions for use and photos of which are presented to your attention, is very often prescribed by specialists during rehabilitation period after suffering inflammation of the meninges.

Are there any contraindications for use?

Since this medication has a very strong effect on the body, it should be taken with extreme caution and only as prescribed by a doctor. The medicine can be purchased at a pharmacy only if you have a prescription from a doctor. So, according to the instructions for use, the use of the drug is prohibited in the following cases:

If a person has excessive sensitivity to the active component of this medicine.
It is strictly prohibited to use the medication for epilepsy, as well as for excessive motor activity of skeletal muscles.
Treatment with this drug should be avoided by patients suffering from diseases of cardio-vascular system. This especially includes angina pectoris and problems with arterial vessels.
Ulcerative chronic diseases digestive system, leading to the formation of serious defects on the walls of the intestines and stomach.
The drug should not be used for prostate adenoma, which is characterized by excessive enlargement of the prostate gland.
Doctors prohibit the use of the product by those patients who have serious intoxication of the body. This is especially true for young children.

Specialists try their best possible ways protect your patients from self-medication. Taking such a serious medication can have a detrimental effect on your health, so be sure to go to the hospital.

"Proserin" in ampoules: instructions for use, method of administration, dosage

Contraindications to the use of this drug have been described above. Now it’s worth figuring out exactly how to use it in order to provide maximum benefit body. As mentioned above, injections of this medicine can be administered subcutaneously, intramuscularly and intravenously. This can only be done by a qualified specialist in a hospital setting, while observing the list of all antiseptic and hygiene rules. The dosage is selected by the doctor individually, depending on the patient’s age, as well as the ailments that bother him.

For myasthenia gravis, the dosage of the medicine is one ampoule per day, which must be administered both subcutaneously and intramuscularly. For achievement maximum effect These two methods of administration must be alternated. If myasthenia gravis has become acute and is accompanied by difficulty breathing and swallowing, then the drug is administered intravenously once, after which experts recommend using the method of injection under the skin.

In the presence of a disease such as atony of the gallbladder or intestines, Proserin in ampoules (instructions for use and reviews from doctors confirm this) should be used in a dosage of 0.25 to 0.5 mg, depending on how severe the disease is. In this case, both subcutaneous and intramuscular administration methods can be used. If patients have overdosed on muscle relaxants, then the drug should be administered intravenously within two minutes. If necessary, the procedure must be repeated one more time.

The drug "Prozerin" in ampoules, the instructions for use for which are very important information, which every patient should become familiar with, can also be used by children, but only in a hospital setting. So, the product can be used even by babies who have not reached the one-year period. In this case, the dosage of the active substance should be about 0.05-0.3 mg per kilogram of body weight. For children under twelve years of age, it is recommended to increase the dosage to 0.2-05 mg. In this case, the regimen, method of application and method of treatment can only be determined by the attending physician. In addition, the individual characteristics of each person, as well as the severity of the disease, must be taken into account.

A few words about side effects

"Proserin" in ampoules, the instructions for use describe it as very serious and effective drug Therefore, treatment issues must be approached with full responsibility. Be prepared for the fact that during treatment with this substance various reactions may occur in the body. pathological processes from all organs and systems. Therefore, if you experience any unpleasant phenomena, tell your doctor immediately. Further adjustments to treatment may depend on this.

More often side effects arise from the digestive system. Many patients complained of diarrhea, nausea, bloating, vomiting, and excessive salivation. In addition, during the use of the drug, deviations from the cardiovascular system often occurred. Not excluded headache, dizziness, weakness and drowsiness. Much less often, patients complained about the development of pathologies of the urinary, supporting and respiratory systems. Also, patients often experience allergic reactions to the components included in the composition. Typically, an allergy makes itself felt in the form of a rash, hives and itchy skin.

Important instructions

The drug "Proserin" in ampoules, the instructions for use and method of administration of which must be studied in as much detail as possible, should be used with extreme caution. Every doctor should consider special instructions and prescribe treatment correctly. If the product is used in sufficiently large dosages, then it is necessary to combine the use of the Proserin solution with Atropine. If the patient has recently undergone surgery on the digestive system or genitourinary organs, then the product can only be used under strict medical supervision. The drug can be prescribed to any child age category. However, it is recommended to do this only in a hospital setting under the strict supervision of the attending physician.

It is very important to consider drug interactions, because prozerin can have different effects on human body, depending on the medications used by the patient. In some cases, the product can also be used by pregnant women. However, this must also be done under the strict supervision of the attending physician. During the course of treatment, the patient must refuse dangerous species activities related to the operation of mechanisms, since the body’s psychomotor reactions may be slow.

What happens in case of overdose?

“Proserin” in ampoules, the instructions for use and composition of which will allow you to use it correctly, must be administered very carefully, taking into account the dosage prescribed by your doctor. If the patient's body enters excessively a large number of active substance, the following may appear adverse reactions, such as tachycardia, problems with intestinal motility and breathing, decreased blood pressure, weakness, as well as unconscious muscle contractions. In case of overdose, treatment with the drug is stopped. In this case, the doctor must carry out symptomatic therapy.

Are there any analogues?

The drug "Prozerin" in ampoules, instructions for use and dosage of which we now know, like any other medicine has analogues. The closest in composition, as well as in the effect it has on the body, is the medicine “Neostigmine sulfate”. You can change the drug only if your doctor recommends it.

"Proserin" in ampoules: instructions for use for dogs

This product can also be used in veterinary medicine. In this case, a 0.05% solution is usually used. The drug is prescribed for birth complications, brain dysfunction after injury, myasthenia gravis, as well as atony of the digestive system and bladder.

How to store it correctly?

The drug "Proserin", like any other medicine, is very important to store correctly. Only in this case the effect of treatment will be maximum. Best before date this tool is thirty-six months from the date of manufacture. However, if you store it under the wrong conditions, this period will be significantly reduced.

Ampoules should be stored in the original cardboard packaging in a dark and dry place. At the same time, place the packaging so that it is inaccessible to children. The storage temperature of this medicine should not exceed twenty-five degrees Celsius.

Cost of medicine

The drug "Proserin" is an old and proven remedy that appeared on the market a relatively long time ago. The average price for a package of solution is about sixty to seventy rubles. Despite such a low cost, the drug has a truly miraculous effect.

conclusions

The drug "Prozerin" in ampoules, the instructions for use and contraindications of which determine the advisability of use, is very effective, but at the same time dangerous means, which can only be purchased on the recommendation of a doctor. Therefore, do not sacrifice your health and approach the treatment process with full responsibility. Start taking care of your health today, and then you won't need medications.

Latest update of the description by the manufacturer 31.07.1998

Filterable list

Active substance:

ATX

Pharmacological group

Composition and release form

1 ampoule with 1 ml of solution for injection contains neostigmine methyl sulfate 0.5 mg; V cardboard box 10 pieces.

1 tablet contains neostigmine bromide - 15 mg; 10 pcs in a strip pack, 2 packs in a cardboard box.

pharmachologic effect

pharmachologic effect- uterotonic, increases smooth muscle contractility, anticholinesterase.

It blocks cholinesterase, resulting in the accumulation of acetylcholine, which excites m- and n-cholinergic receptors.

Indications of the drug Proserina injection solution 0.05%

Myasthenia gravis, paralysis, poliomyelitis, encephalitis, weakness labor activity, optic nerve atrophy, neuritis, glaucoma, atony of the stomach, intestines and bladder.

Contraindications

Epilepsy, hyperkinesis, bronchial asthma, angina pectoris, atherosclerosis.

Side effects

Hypersalivation, nausea, vomiting, bradycardia, hypotension, weakness, twitching of the tongue muscles, tremor.

Directions for use and doses

SC - 0.5 mg (1 ml of 0.05% solution) 1-2 times a day; children - 0.05 mg per year of life, but not more than 0.75 ml of a 0.05% solution.

Orally - 0.015 g 2-3 times a day. Higher doses: single - 0.015 g, daily - 0.05 g. Course - 25-30 days, interval between courses - 3-4 weeks.

Storage conditions for the drug Proserina injection solution 0.05%

In a place protected from light.

Keep out of the reach of children.

Shelf life of the drug Proserina solution for injection 0.05%

tablets 0.015 g - 5 years.

injection solution 0.05% - 4 years.

Do not use after the expiration date stated on the package.

Prozerin is a synthetic cholinesterase inhibitor. This is an effective, well-studied drug. When prescribed correctly, it works great and helps solve wide range various problems in the field of neuroscience.

Despite numerous positive results, taking the drug without consulting a doctor and preliminary diagnosis is strictly prohibited. Prozerin has many side effects and a large list of contraindications.

Description of the drug

Forms of release of the drug

The medicine is produced in white and blue cardboard boxes. One package contains 10 ampoules in contour cardboard, each containing 1 ml of the drug ( clear liquid without sediment). In addition to the medicine itself, the box contains instructions in two languages and a ceramic cutting disc for opening ampoules. There are packages without a disk, inside there are special ampoules with a place for breaking.

Main active ingredient

The drug contains: prozerin and special water for injection. This substance is a man-made cholinesterase blocker.

It affects the body as follows. The frequency of heart contractions decreases, the secretion of sweat, salivary and bronchial glands increases, internal eye pressure decreases, and the pupil narrows. The tone of the smooth and skeletal muscles. Hypersalivation and bronchorrhea develop, the acidity of the juice in the stomach increases, and eye pressure decreases.

What is it used for?

The range of diseases for which this drug is used is quite wide. Among them:

Problems with the musculoskeletal system due to brain injuries;
Atrophy optic nerve and various neuritis;
Restoring the body after meningitis, encephalitis and polio;
Atony of the elements gastrointestinal tract And genitourinary system;
Sometimes used for weak labor;
Myasthenia;
Residual disturbances of neuromuscular transmission by non-depolarizing muscle relaxants;
Open angle glaucoma.

Contraindications for use

Regardless dosage form, Prozerin has a number of limitations. Among them:

Various forms of arrhythmia;
Bronchial asthma;
Bradycardia;
Cardiac ischemia;
Angina;
Thyrotoxicosis;
Prostatic hyperplasia;
Gastric ulcers of the duodenum;
Peritonitis;
Any infectious diseases in acute form;
Severe atherosclerosis;
Vagotomy, hyperkinesis;
Individual sensitivity to the ingredients of the drug.

In addition to the above, the medication should not be used by pregnant women at any stage and nursing mothers.

The list of contraindications for each patient may expand, so if you have chronic diseases, be sure to tell your doctor about this before starting treatment.

How to take it correctly

How to give an injection correctly

The drug can be administered subcutaneously, intravenously and intramuscularly. The daily dose and duration depend on the disease, on average the recommendations are as follows:

For myasthenia gravis, the maximum daily dose is 0.5 mg. The course is usually long, during which the input routes are constantly changing.
In case of acute myasthenic crisis, when breathing is difficult, 0.5-1 ml is administered intravenously. When the condition stabilizes, the solution begins to be injected subcutaneously.
For the treatment of postoperative atony of the genitourinary system or gastrointestinal tract, as well as the prevention of urinary retention after surgical interventions, the drug is administered 0.25 mg intramuscularly or subcutaneously. In this case, the course of treatment lasts three to four days after surgery.
If Prozerin is used as an antidote to muscle relaxants, then the drug is administered at 0.5 - 2 mg intravenously. If necessary, the injections are repeated.
For children, the maximum dose is 00.05 mg per year of life. Treatments are carried out only in a hospital, under the close supervision of a doctor.
If the patient needs to be given large doses Proserina, then atropine sulfate is simultaneously administered to prevent side effects
The recommendations described above are average values that are not clear-cut. Based individual characteristics patient, the doctor can change the dose, course duration and methods of administration.

Proserin may interact with other medications and change their effect, so if you are taking or have recently taken other medications, tell your doctor before starting treatment.

Side effects

If the dosage is incorrectly selected or intolerance, the drug can cause numerous side effects throughout the body. Among them: arrhythmia, diarrhea, rash, tremor, drowsiness, weakness, decreased blood pressure, spasms, headache, convulsions, shortness of breath, difficulty breathing, flatulence, vomiting, nausea, and others. If you feel worse or overdose, reduce the amount of medication or stop taking it altogether. During the course, it is better to refrain from driving a car and other activities that require high concentration of attention.

Price and closest analogues

The average price is approximately 50 Russian rubles.

Medications similar in composition and effect include: Oxazil, Ubretide, Neostigmine methylsulfate, Armin, Amiridine.

Ubretide Amiridin

The drug Proserin is a synthetic drug, the main active ingredient of which is called neostigmine methyl sulfate. This medicine is included in the list of the most important and vital drugs.

Prozerin: its composition and properties

In 1 ml of solution - 0.5 mg of neostigmine. Additional excipient- water for injections.

Proserin injections have a pronounced anticholinesterase effect, that is, they contribute to a significant improvement in the process of transmitting the excitatory impulse from the nerve to skeletal muscle, improve motility of the gastrointestinal tract and tone of the bladder and bronchi, as well as the secretion of endocrine glands. Among other things, the use this drug greatly enhances the cholinergic effects in the eyes and many internal organs.

Prozerin injections in your own way pharmacological action are close to eserine, however, the latter drug is less stable and less well tolerated in therapeutic doses. Prozerin weakens the activity of an enzyme called cholinesterase, thereby preventing the destruction of acetylcholine and promoting its accumulation in tissues.

While using the drug, it is advisable to refrain from driving a car independently, as well as from types of labor activity that require concentration.

Application of Proserin

This drug is used in many branches of medicine. So, in neurology Proserin is used for:

myasthenia gravis (i.e. muscle weakness);
paresis (weakening of voluntary movements) and paralysis;
(inflammation of peripheral nerves);
disorders caused by brain injuries;
recovery period after tuberculous meningitis and encephalitis.

This medicine found wide application in ophthalmology (to reduce intraocular pressure, increasing with, as well as for constriction of the pupil) and obstetrics (to stimulate labor and as an anesthetic).

Therapists also use Prozerin, prescribing it as a preventive and medicinal remedy for atony (loss of tone) of the bladder, intestines and stomach.

Proserin: method of application

The dosage of the drug depends on many factors. When administered orally - 0.015 g of the drug 2 or 3 times a day, when administered subcutaneously - 1 ml of 0.05% 1 or 2 times a day.

If it is necessary to relieve the effect of muscle relaxants, atropine sulfate is first administered intravenously - 0.5-0.7 ml of solution (0.1%). After the pulse begins to accelerate, the drug Proserin is administered intravenously - 3 ml. Maximum dose–12 ml of solution (0.05%).

If it is necessary to stimulate labor, Prozerin is administered subcutaneously - 1 ml 1-2 times per hour. For the first time, 1 ml of atropine sulfate solution (0.01%) is administered simultaneously with Proserin.

Possible side effects

When using Proserin, the following consequences are possible:

hypersalivation, that is, excessive salivation;
frequent urination;
digestive system disorder in the form of vomiting;
visual impairment;
(rare pulse);
headache and dizziness;
increased bronchial tone;
decreased blood pressure;
twitching of skeletal muscles, as well as the muscles of the tongue;
allergic reactions in the form of itching and rash;
general weakness.

Contraindications and interactions with other drugs

Contraindications:

bronchial asthma;
atherosclerosis;
bradycardia (slow pulse);
obstruction (mechanical) of the urinary tract;
obstruction of the gastrointestinal tract;
hyperkinesis (involuntary contraction of the muscles of the limbs);
sensitivity and reaction to certain components of the drug.

Regarding the period of pregnancy and lactation breast milk, then Prozerin can be prescribed only in extreme cases, since the drug penetrates the placenta and milk.

In case of an overdose of Proserin, it is necessary to stop taking it or reduce the dosage. In some cases, anticholinergics (Atropine and Metacin) are used.

The effect of Prozerin is reduced by M-anticholinergic blockers, ganglion blockers, quinidine, local anesthetics, tricyclic antidepressants, procainamides, antiparkinsonian and antiepileptic drugs. The effect is enhanced when interacting with Ephedrine. A decrease in heart rate is also possible when the drug is combined with beta-blockers.

Prozerin is not a drug that you can prescribe to yourself. Only after a thorough examination of the patient’s condition can the attending physician prescribe this medication, establishing the required dosage and duration of use.

Prozerin is a synthetic drug with strong reversible anticholinesterase activity, used to treat diseases of the nervous system.

pharmachologic effect

The active component of Prozerin is a synthetic anticholinesterase substance that promotes the accumulation and enhancement of the effect of acetylcholine on tissues and organs, as well as the restoration of neuromuscular conduction.

As a result of the use of Proserin, the secretion of the salivary, sweat and bronchial glands increases, the tone of intestinal smooth muscles increases, intraocular pressure decreases. In addition, Prozerin, according to the instructions, tones the skeletal muscles and causes bronchospasm.

Release form

Prozerin is produced in the form:

Solution for injection containing 0.5 mg active substance in 1 ml, in ampoules of 1 ml;
White tablets containing 15 mg of active substance, 20 pieces per package.

For children, Proserin is produced in the form of pinkish-cream granules for the preparation of a suspension for oral administration, 60 g in 150 ml bottles.

The closest analogues of Proserin in terms of the mechanism of action are the drugs Amiridin, Armin, Ubretide, Deoxypeganine hydrochloride, Oxazil, Neuromidin.

Indications for use of Proserin

According to the instructions, Proserin is used for treatment:

Myasthenia;
Paralysis;
Open angle glaucoma;
Optic nerve atrophy;
Movement disorders caused by brain injuries;
Neuritis;
Atony of the gastrointestinal tract and bladder.

In addition, the use of Prozerin is effective:

IN recovery period after suffering from polio, meningitis, encephalitis;
To eliminate residual disorders of neuromuscular transmission with non-depolarizing muscle relaxants;
In rare cases - with weakness of labor.

Contraindications

According to the instructions, Proserin is contraindicated for use in:

Epilepsy;
Bradycardia;
Angina pectoris;
Severe atherosclerosis;
Peptic ulcer of the stomach and duodenum;
Mechanical obstruction of the gastrointestinal tract and urinary tract;
Intoxication in weakened children;
Coronary heart disease;
Arrhythmias;
Bronchial asthma;
Thyrotoxicosis;
Peritonitis;
Prostate hypertrophy;
Hypersensitivity to the components of Proserin.

In addition, the use of Proserin is contraindicated during acute infectious disease , pregnancy and lactation.

How to use Proserin

As a rule, according to indications, Proserin is taken half an hour before meals, one tablet no more than three times a day.

Children under 10 years of age - 1 mg of the drug per day for each year of life;
Children over 10 years old - no more than 10 mg of Proserin per day.

According to indications, Prozerin is prescribed subcutaneously several times a day., the maximum single dosage should not exceed 2 mg. Most daily dose recommended for use in daytime, which accounts for the greatest degree of fatigue. Average duration The course of treatment is thirty days.

For myasthenia gravis, one Proserin tablet per day or 0.5 mg of the drug intravenously is prescribed. The course of treatment is usually long, during which it is recommended to change the route of administration of the drug. When treating myasthenia gravis, it is effective to carry out complex treatment simultaneously with GCS, aldosterone antagonists and anabolic hormones.

For prophylaxis against postoperative atony of the bladder and intestines, Proserin is used subcutaneously or intravenously at 0.25 mg every 4-6 hours for 3-5 days. To treat urinary retention, it is recommended to administer 5 injections of 0.5 mg at an interval of three hours.

According to reviews, Proserin is effective in reducing intraocular pressure, for which 1-2 drops of a 0.5% solution are instilled into the conjunctival sac up to four times a day.

Proserin is taken orally when labor is weak, 3 mg up to six times a day with an interval of 40 minutes. The interval for subcutaneous administration is one hour, and 1 ml of a 0.05% solution should be administered 1-2 times in combination with a solution of atropine sulfate.

When using Prozerin as an antidote to muscle relaxants, 0.5-2 mg of the drug is administered intravenously slowly.

Side effects of Proserin

According to reviews, Proserin can cause significant side effects, which appear as:

Vomiting, hypersalivation, spastic contraction of intestinal motility, flatulence, nausea, diarrhea;
Spasms of skeletal muscles, tremors, including twitching of the tongue muscles, dysarthria, convulsions, arthralgia;
Profuse sweating;
Loss of consciousness, dizziness, headache, weakness, drowsiness;
Increased urination;
Visual impairment, miosis;
Respiratory depression, shortness of breath, bronchospasm;
Brady- or tachycardia, nonspecific changes on the ECG, arrhythmias, junctional rhythm, AV block, cardiac arrest.

A decrease in blood pressure is most often observed with parenteral administration. Allergic reactions, which appear when using Proserin according to reviews, usually appear as a rash, anaphylaxis, facial flushing and itching.

The main symptoms of an overdose of Proserin according to the instructions include:

Bradycardia;
Reduced blood pressure;
Miosis;
Nausea;
Increased urination;
Gradual development of general weakness;
Diarrhea;
Hypersalivation;
Bronchospasm;
Increased peristalsis;
Twitching of tongue and skeletal muscles.

Storage conditions

According to indications, Proserin is dispensed with a doctor’s prescription. The shelf life of granules is 24 months, ampoules – 36 months, tablets – 5 years.