Pharmacodynamics
Enhances the inhibitory effect of gamma-aminobutyric acid (GABA) on the transmission of nerve impulses. Stimulates benzodiazepine receptors located in the allosteric center of postsynaptic GABA receptors of the ascending activating reticular formation brainstem and lateral horn interneurons spinal cord; reduces the excitability of subcortical structures of the brain (limbic system, thalamus, hypothalamus), inhibits polysynaptic spinal reflexes.

The anxiolytic effect is due to the influence on the amygdala complex of the limbic system and manifests itself in a decrease in emotional stress, easing anxiety, fear, and restlessness.

The sedative effect is due to the influence on the reticular formation of the brain stem and nonspecific nuclei of the thalamus and is manifested by a decrease in symptoms of neurotic origin (anxiety, fear).

The productive symptoms of psychotic origin (acute delusional, hallucinatory, affective disorders) are practically not affected; a decrease in affective tension and delusional disorders is rarely observed.

The hypnotic effect is associated with inhibition of the cells of the reticular formation of the brain stem. Reduces the impact of emotional, vegetative and motor stimuli that disrupt the mechanism of falling asleep.

The anticonvulsant effect is realized by enhancing presynaptic inhibition, suppresses the propagation of the convulsive impulse, but does not relieve the excited state of the focus. The central muscle relaxant effect is due to inhibition of polysynaptic spinal afferent inhibitory pathways (to a lesser extent, monosynaptic ones). Direct inhibition of motor nerves and muscle function is also possible.

Pharmacokinetics
After oral administration, it is well absorbed from the gastrointestinal tract (GIT), the time to reach maximum concentration (TCmax) in the blood plasma is 1-2 hours. Metabolized in the liver. The half-life (T1/2) is 6-10-18 hours. It is excreted mainly by the kidneys in the form of metabolites.

As an anticonvulsant - temporal and myoclonic epilepsy.

In neurological practice, Phenazepam ® is used to treat hyperkinesis and tics, muscle rigidity, and autonomic lability.

Carefully
Use with caution in case of hepatic and/or renal failure, cerebral and spinal ataxia, history of drug dependence, tendency to abuse psychoactive drugs, hyperkinesis, organic diseases brain, psychosis (paradoxical reactions are possible), hypoproteinemia, sleep apnea (established or suspected), elderly patients.

Use immediately before or during childbirth may cause respiratory depression in the newborn, decreased muscle tone, hypotension, hypothermia and weak sucking ("floppy baby" syndrome).

Symptoms: severe depression of consciousness, cardiac and respiratory activity, severe drowsiness, prolonged confusion, decreased reflexes, prolonged dysarthria, nystagmus, tremor, bradycardia, shortness of breath or difficulty breathing, decreased blood pressure, coma.

Treatment: gastric lavage, intake activated carbon, hemodialysis is ineffective, monitoring the vital functions of the body, maintaining respiratory and cardiovascular activity, symptomatic therapy. Specific antagonist fpumazenil (in a hospital setting) (0.2 mg intravenously, if necessary, up to 1 mg in a 5% glucose solution or 0.9% sodium chloride solution).

Phenazepam may increase the toxicity of zidovudine.

There is a mutual enhancement of the effect with the simultaneous use of antipsychotic, antiepileptic or sleeping pills, as well as central muscle relaxants, narcotic analgesics, ethanol.

Microsomal oxidation inhibitors increase the risk of toxic effects. Inducers of microsomal liver enzymes reduce effectiveness.

Increases the concentration of imipramine in the blood serum.

When used simultaneously with antihypertensive drugs, the antihypertensive effect may be enhanced. Increased respiratory depression may occur during concomitant administration of clozapine.

Patients who have not previously taken psychoactive drugs exhibit a therapeutic response to the use of phenazepam in lower doses compared to patients taking antidepressants, anxiolytics, or alcoholism.

Like other benzodiazepines, it has the ability to cause drug dependence when taken long-term in large doses (more than 4 mg/day). If you suddenly stop taking it, withdrawal symptoms may occur (including depression, irritability, insomnia, increased sweating), especially with long-term use (more than 8-12 weeks). If patients experience unusual reactions such as increased aggressiveness, acute conditions agitation, fear, suicidal thoughts, hallucinations, increased muscle cramps, difficulty falling asleep, shallow sleep, treatment should be discontinued.

During treatment, patients are strictly prohibited from consuming ethanol.

The effectiveness and safety of the drug in patients under 18 years of age have not been established.

Impact on the ability to drive vehicles and operate machinery
During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

10 or 25 tablets in a blister pack made of polyvinyl chloride film and printed varnished aluminum foil.

50 tablets in polymer jars with a tamper evident lid.

Each jar, 5 blister packs of 10 tablets each or 2 blister packs of 25 tablets, along with instructions for use, are placed in a cardboard pack.

For epilepsy, the dose is 2-10 mg/day

For alcohol withdrawal, Phenazepam is prescribed at a dose of 2.5-5 mg/day

For diseases with increased muscle tone, the drug is prescribed at a dose of 2-3 mg 1-2

To avoid the development of drug dependence during a course of treatment, the duration of use of Phenazepam is 2 weeks. In some cases, the duration of treatment can be increased to 2 months. When discontinuing npenapata, the dose is reduced gradually.

Overdose

Phenazepam is a fairly common drug in medicine, which is used mainly to affect the central nervous system ( CNS) person. According to its medicinal effect, it belongs to the group tranquilizers, as it suppresses the activity of many nerve centers. Thanks to this, many different effects are achieved.

Most often, phenazepam is used to achieve the following effects:

• Sedative. Sedation is a calming effect in various excited states. This is what is often needed in psychiatry.
• Anticonvulsant. An anticonvulsant or anticonvulsant effect is necessary to quickly relieve the patient's seizure syndrome. Otherwise, there is a risk of disruption of vital functions ( stopping breathing or heartbeat, irreversible organ damage). To relieve seizures in practice, it is often not phenazepam that is used, but other drugs from its group. The anticonvulsant effect is important for providing urgent assistance at convulsive syndrome.
• Anxiolytic. This effect similar in effect to a sedative. It consists in eliminating anxiety states and strong experiences. It is also often used in psychiatry.
• Muscle relaxant. This effect involves relaxation of most muscles in the body. It is often used in anesthesiology to prepare the body for surgery. However, with phenazepam this muscle relaxant effect is relatively weakly expressed.
• Hypnotic. High doses of phenazepam give a pronounced hypnotic effect. It is also often used in psychiatry to calm violent and agitated patients.

Phenazepam is one of the most potent substances among benzodiazepines. Potentially, it can cause quite strong addiction in the future and, as a result, withdrawal symptoms. In most countries, the sale of phenazepam without a prescription is prohibited due to high danger for health if used incorrectly. It is also prohibited to transport this drug across the border without accompanying documents ( a certificate from a doctor stating that the passenger needs the drug).

Pharmacological group of phenazepam

Along with phenazepam, the group of benzodiazepines includes the following drugs:

• diazepam;
• lorazepam;
• alprazolam;
• clonazepam;
• midazolam, etc.

After consultation with your doctor or pharmacist, phenazepam can be replaced with the following analogues(drugs with the same active ingredient):

• phenorelaxan;
• fesanef;
• fesipam;
• elzepam;
• tranquesipam.

How to spell phenazepam in Latin?

The mechanism of action of the drug phenazepam

The effect of taking phenazepam is achieved through the following mechanisms:

• decreased activity of subcortical brain structures;
• stimulation of GABA receptors ( reduces the conduction of nerve impulses);
• weakening and inhibition of spinal reflexes;
• influence on the amygdala ( one of the brain structures) reduces emotional experiences, anxiety, fear, etc.;
• inhibition of cells of the reticular formation ( one of the brain structures) reduces irritation of the nervous system and facilitates the process of falling asleep;
• influence on nonspecific nuclei of the thalamus ( one of the brain structures);
• motor inhibition ( motor) impulse ensures the cessation of cramps and muscle relaxation.

How much phenazepam is found in blood and urine?

It should be noted that with some liver or kidney diseases, the period for complete elimination of the drug from the body may increase slightly. This is explained by the fact that it is the liver and kidneys that “neutralize” phenazepam and promote its excretion in the urine. In case of severe disturbances in the functioning of these organs, the drug is not prescribed precisely because it for a long time will not be excreted from the body.

Indications for use of phenazepam

Most often, phenazepam is prescribed for the following diseases and pathological conditions:

• reactive psychoses;
• pathological irritability;
• increased anxiety;
• nervous breakdowns;
• unreasonable change of mood ( emotional lability);
• withdrawal syndrome (withdrawal) after stopping taking alcohol or drugs;
• some disorders of the autonomic nervous system;
• nervous tics;
• in some convulsive conditions;
• in some forms of schizophrenia;
• for some forms of epilepsy;
• panic states;
• some phobias;
• for premedication ( medication preparation) before surgery.

Does phenazepam help with fears and panic attacks?

It should be noted that in all these cases, phenazepam is not the drug of choice, since its effect on the body will be complex. There are anxiolytics with a narrower spectrum of action, the use of which will be safer and more effective. However, if the patient is susceptible to phenazepam, it can be prescribed as a rather long course of treatment. Of course, the patient must be regularly monitored by a specialist.

Contraindications to the use of phenazepam

All contraindications can be divided into relative and absolute. Relative contraindications imply that the harm to health will be moderate, and the drug can be used if the doctor, for example, does not have access to its analogues, and the patient’s condition will deteriorate significantly without taking phenazepam. Absolute contraindications categorically exclude the use of phenazepam, since a sharp deterioration in the patient’s health will most often create a direct threat to life or cause irreversible damage.

Contraindications to the use of phenazepam

Is it possible to use phenazepam during pregnancy and lactation (feeding)?

In the second and third trimesters, the use of phenazepam is possible, but not advisable. During this period, the risk of birth defects decreases, but the child's health is still at risk. The risk of various complications during pregnancy increases. Taking the drug on the eve of birth may cause the baby to have breathing problems after birth. However, the use of phenazepam during pregnancy is permissible for health reasons ( if taking a drug can save the patient’s life, and doctors do not have safer means).

During breastfeeding, phenazepam can be excreted from the mother's body in small quantities with milk and thus enter the baby's body. Even these negligible doses can affect his health. Therefore, the use of phenazepam during lactation is also not recommended.

Is it possible to drink alcohol and phenazepam?

Since phenazepam can potentially inhibit vital processes ( breathing and heartbeat), taking it simultaneously with alcohol is simply life-threatening. The degree of danger is directly proportional to the dose of alcohol and the drug. If you regularly take phenazepam for a long time, alcohol should not be consumed throughout the entire course of treatment. Only after a gradual reduction in the dose and then complete withdrawal of the drug can you drink alcohol. In most cases, it is better to discuss the time of their use and dose in advance with your doctor.

At what age can children take phenazepam?

If a child takes the standard adult dose of phenazepam, there is a high risk of overdose or serious side effects. The most severe of them are severe disturbances of consciousness, breathing, heartbeat, and coma. The problem is that smaller doses can give the same effect ( After all, a child’s body is more sensitive). That is why this drug is not prescribed to children.

Can patients with diabetes mellitus use phenazepam?

The point is that when diabetes mellitus Some internal organs may be damaged. Pathology of these organs can change the effect of taking phenazepam. For example, with diabetic nephropathy, the drug will be eliminated from the body more slowly, therefore, its effect may be longer and more toxic. The risk of overdose and side effects increases.

Instructions for use of the drug phenazepam

Take the tablets with a small amount of liquid. Synchronizing the intake of tablets with food is not of fundamental importance. Most often, phenazepam is taken at night to avoid the side effect of drowsiness during the day. Ampoules with solution are sold in ready-to-use form. The solution is drawn into a syringe and injected into a muscle or vein. After administering or consuming phenazepam, it is recommended to stay at home and not engage in work that requires high concentration or physical exertion.

Shelf life of the drug phenazepam

What is dangerous about expired tranquilizer phenazepam?

Dosage and method of use of phenazepam

Approximate dosages of phenazepam for various pathologies

For most pathologies, the average single dose is 0.5 - 1 mg, and the average daily dose is 1.5 - 5 mg ( divided into several steps). The maximum daily dose is 10 mg, in rare cases it may be slightly exceeded.

All dosages are approximate, since each specific pathology requires one or another effect ( and it depends on the dose of the drug). Patients should strictly adhere to the dose prescribed by their doctor. Self-administration of the drug without consulting a doctor is dangerous even in subtherapeutic doses ( less than the minimum specified in the table).

How long does the course of treatment with phenazepam tablets and injections last?

If we are talking about neuroses, psychoses, epilepsy and some other diseases for which a course of phenazepam is really necessary, then it lasts on average about two weeks. During this time, if taken correctly, patients will not have time to develop dependence on the drug and will not experience withdrawal symptoms. In some cases, the course duration can reach 1 – 2 months ( at the discretion of the doctor), but then the drug will have to be discontinued gradually.

Is it possible to overdose on phenazepam (poisoning)?

An overdose of phenazepam can be recognized by the following symptoms and signs:

• severe confusion and disorientation;
• depression of heartbeat ( weak pulse, slow heartbeat, etc.);
• respiratory depression ( superficial, rare breathing );
• weakening of reflexes ( knee, elbow, etc.);
• severe drowsiness;
• decreased blood pressure;
• dizziness, tinnitus, nausea;
• involuntary trembling in the limbs ( tremor);
• fast involuntary movements pupils ( vertical or horizontal).

In case of an overdose of phenazepam, the patient should be urgently taken to the hospital. The main treatment is gastric lavage and the use of sorbents ( activated carbon, etc.). Hemodialysis to remove the drug from the blood usually does not provide sufficient effect. It is possible to prescribe flumazenil ( already in the hospital). Also, if necessary, support breathing and heartbeat.

How many milligrams ( mg) should I take phenazepam for sleep?

What is the difference between phenazepam tablets and phenazepam injections ( in injections)?

Once the tablets enter the body, they pass through the esophagus and stomach, and only in the intestines is the drug absorbed into the circulatory system. For passing upper sections the gastrointestinal tract takes some time, so phenazepam will act more slowly. At intramuscular injection (usually in the gluteal muscle) the drug enters the blood faster, and the time for the onset of effect is reduced. The fastest effect is achieved with intravenous administration, since the solution enters directly into the bloodstream. It has also been noted that the faster the effect of using the drug occurs, the less it lasts.

It should be noted that phenazepam in injections is somewhat more likely to cause side effects and the risk of overdose is higher if the dose is selected incorrectly. Therefore, doctors mainly try to prescribe pills ( especially if long-term use is necessary). Intravenous administration Can be used once in emergency situations. For example, phenazepam may be administered to a patient under anesthesia in case of high blood pressure if other drugs do not help. It is also preferable to give an injection when panic attack or an attack of epilepsy. Anyway The right way The use of the drug for a specific pathology will be advised by the attending physician.

Possible side effects of phenazepam

The following side effects may occur when using phenazepam:

• Skin rash and itching. Most often, these symptoms are a sign of intolerance to certain components of the drug and represent a form of allergic reaction.
• Drowsiness, fatigue and apathy. They are manifestations of a sedative effect and are quite common. Due to these side effects, phenazepam is not recommended for use by drivers, dispatchers and representatives of other professions that require increased attention during work.
• Headache. It is a fairly common side effect, but it does not appear regularly and not in all patients.
• Depression. They are a consequence of depression of the central nervous system. These symptoms may accompany the patient throughout the course of treatment. If you are suicidal, try not to prescribe the drug.
• Coordination problems. May be expressed in instability, unsteadiness of gait, unusual movements. The by-effect appears rarely and mainly during treatment with high doses of the drug.
• Blurred consciousness and memory loss. They are a consequence of CNS depression and are quite common throughout treatment.
• Tremor (involuntary tremors in the limbs). It is observed very rarely. In patients with epilepsy, the drug may cause a seizure.
• Libido disorders (increased or decreased sexual desire). Explained by the impact on certain zones in the central nervous system.
• Urinary disorders. Both urinary retention and incontinence may occur.
• Disturbances at the level of the gastrointestinal tract ( Gastrointestinal tract) . Disorders can be varied and affect the functioning of various organs. They are explained by intolerance to the drug or disturbances in the innervation of smooth muscles that control the functioning of the gastrointestinal tract. There may be drooling or dry mouth, heartburn, vomiting, or abdominal pain. During treatment, the patient may suffer from constipation or, conversely, diarrhea ( stomach upset).
• Dysmenorrhea. In women, long-term use may cause menstrual irregularities.
• Decreased blood pressure. Rare side effect.
• Weight loss. It may occur during long-term use of the drug due to lack of appetite and gastrointestinal disorders.
• Visual impairment(double vision, lack of clarity, foggy vision). It is observed rarely, mainly when taking high doses of the drug.
• Congenital malformations. Occurs in children if the mother took the drug during pregnancy in the first trimester.

Very rarely, when using phenazepam, so-called paradoxical side effects occur ( opposite to the main effect of the drug). For example, an attack of psychosis or severe agitation is possible.

In general, it should be noted that most of the side effects listed above appear only during long-term use or after changing the dosage during the course of treatment. If you follow your doctor's instructions, the likelihood of these disorders occurring is greatly reduced.

Does phenazepam cause hallucinations?

Can phenazepam be taken in old age?

Price for the drug phenazepam

Is it possible to buy phenazepam in an online pharmacy with delivery ( Moscow, Saint Petersburg)?

Online pharmacies that can deliver phenazepam

Which doctor prescribes phenazepam?

F29 Non-organic psychosis, unspecified F40 Phobic anxiety disorders F41.0 Panic disorder [episodic paroxysmal anxiety] F41.1 Generalized anxiety disorder F41.2 Mixed anxiety and depressive disorder F43 Reaction to severe stress and adaptation disorders F45.3 Somatoform dysfunction of the autonomic nervous system F48. 0 Neurasthenia F50.2 Bulimia nervosa F51.2 Sleep-wake disorder of non-organic etiology G40 Epilepsy G41 Status epilepticus Z51.4 Preparatory procedures for subsequent treatment, not classified elsewhere

Pharmacological group

Tranquilizer (anxiolytic)

pharmachologic effect

Anxiolytic drug (tranquilizer) of the benzodiazepine series. It has anxiolytic, sedative-hypnotic, anticonvulsant and central muscle relaxant effects.

Strengthens the inhibitory effect of GABA on the transmission of nerve impulses. Stimulates benzodiazepine receptors located in the allosteric center of postsynaptic GABA receptors of the ascending activating reticular formation of the brain stem and interneurons of the lateral horns of the spinal cord; reduces the excitability of subcortical structures of the brain (limbic system, thalamus, hypothalamus), inhibits polysynaptic spinal reflexes.

The anxiolytic effect is due to the influence on the amygdala complex of the limbic system and manifests itself in a decrease in emotional stress, easing anxiety, fear, and restlessness.

The sedative effect is due to the influence on the reticular formation of the brain stem and nonspecific nuclei of the thalamus and is manifested by a decrease in symptoms of neurotic origin (anxiety, fear).

The productive symptoms of psychotic origin (acute delusional, hallucinatory, affective disorders) are practically not affected; a decrease in affective tension and delusional disorders is rarely observed.

The hypnotic effect is associated with inhibition of the cells of the reticular formation of the brain stem. Reduces the impact of emotional, vegetative and motor stimuli that disrupt the mechanism of falling asleep.

The anticonvulsant effect is realized by enhancing presynaptic inhibition, suppresses the propagation of the convulsive impulse, but does not relieve the excited state of the focus. The central muscle relaxant effect is due to inhibition of polysynaptic spinal afferent inhibitory pathways (to a lesser extent, monosynaptic ones). Direct inhibition of motor nerves and muscle function is also possible.

Pharmacokinetics

After oral administration, it is well absorbed from the gastrointestinal tract, T max - 1-2 hours. Metabolized in the liver. T 1/2 - 6-10-18 hours. Excreted mainly by the kidneys in the form of metabolites.

Neurotic, neurosis-like, psychopathic and psychopath-like and other conditions (irritability, anxiety, nervous tension, emotional lability), reactive psychoses and senesto-hypochondriacal disorders (including those resistant to the action of other anxiolytic drugs (tranquilizers), obsession, insomnia, withdrawal syndrome (alcoholism, substance abuse), status epilepticus, epileptic seizures (of various etiologies), temporal lobe and myoclonic epilepsy.

In extreme conditions - as a means of facilitating overcoming feelings of fear and emotional stress.

As antipsychotic- schizophrenia with increased sensitivity to antipsychotic drugs (including febrile form).

In neurological practice - muscle rigidity, athetosis, hyperkinesis, tic, autonomic lability (paroxysms of sympathoadrenal and mixed nature).

In anesthesiology - premedication (as a component of induction anesthesia).

Coma, shock, myasthenia gravis, angle-closure glaucoma (acute attack or predisposition), acute poisoning with alcohol (with weakening of vital functions), narcotic analgesics and hypnotics, severe COPD (possible increased respiratory failure), acute respiratory failure, severe depression (may occur suicidal tendencies); I trimester of pregnancy, lactation period, childhood and adolescence up to 18 years (safety and effectiveness have not been determined), hypersensitivity (including to other benzodiazepines).

From the central nervous system and peripheral nervous system: at the beginning of treatment (especially in elderly patients) - drowsiness, fatigue, dizziness, decreased ability to concentrate, ataxia, disorientation, gait instability, slowed mental and motor reactions, confusion; rarely - headache, euphoria, depression, tremor, memory loss, impaired coordination of movements (especially at high doses), depressed mood, dystonic extrapyramidal reactions (uncontrolled movements, including the eye), asthenia, myasthenia gravis, dysarthria, epileptic seizures (in patients with epilepsy); extremely rarely - paradoxical reactions (aggressive outbursts, psychomotor agitation, fear, suicidal tendencies, muscle spasms, hallucinations, agitation, irritability, anxiety, insomnia).

From the hematopoietic organs: leukopenia, neutropenia, agranulocytosis (chills, pyrexia, sore throat, excessive fatigue or weakness), anemia, thrombocytopenia.

From the digestive system: dry mouth or drooling, heartburn, nausea, vomiting, decreased appetite, constipation or diarrhea; liver dysfunction, increased activity of liver transaminases and alkaline phosphatase, jaundice.

From the genitourinary system: urinary incontinence, urinary retention, renal dysfunction, decreased or increased libido, dysmenorrhea.

Allergic reactions: skin rash, itching.

Local reactions: phlebitis or venous thrombosis (redness, swelling or pain at the injection site).

Others: addiction, drug dependence; decrease in blood pressure; rarely - visual impairment (diplopia), weight loss, tachycardia.

If the dose is sharply reduced or taken is stopped, withdrawal syndrome occurs (irritability, nervousness, sleep disturbances, dysphoria, spasm of smooth muscles of internal organs and skeletal muscles, depersonalization, increased sweating, depression, nausea, vomiting, tremor, perception disorders, incl. hyperacusis, paresthesia, photophobia; tachycardia, convulsions, rarely - acute psychosis).

special instructions

Use with caution in case of liver and/or renal failure, cerebral and spinal ataxia, history of drug dependence, tendency to abuse psychoactive drugs, hyperkinesis, organic brain diseases, psychosis (paradoxical reactions are possible), hypoproteinemia, sleep apnea (established or suspected ), in elderly patients.

In case of renal and/or liver failure and long-term treatment, it is necessary to monitor the peripheral blood picture and the activity of liver enzymes.

Patients who have not previously taken psychoactive drugs exhibit a therapeutic response to the use of phenazepam in lower doses compared to patients taking antidepressants, anxiolytics, or alcoholism.

Like other benzodiazepines, it has the ability to cause drug dependence when taken long-term in large doses (more than 4 mg/day). If you suddenly stop taking it, withdrawal symptoms may occur (including depression, irritability, insomnia, increased sweating), especially with long-term use (more than 8-12 weeks). If patients experience unusual reactions such as increased aggressiveness, acute states of agitation, feelings of fear, thoughts of suicide, hallucinations, increased muscle cramps, difficulty falling asleep, shallow sleep, treatment should be discontinued.

During treatment, patients are strictly prohibited from consuming ethanol.

The effectiveness and safety of the drug in patients under 18 years of age have not been established.

In case of overdose, severe drowsiness, prolonged confusion, decreased reflexes, prolonged dysarthria, nystagmus, tremor, bradycardia, shortness of breath or difficulty breathing, decreased blood pressure, and coma are possible. Gastric lavage and activated charcoal are recommended; symptomatic therapy (maintaining breathing and blood pressure), administration of flumazenil (in a hospital setting); hemodialysis is ineffective.

Impact on the ability to drive vehicles and operate machinery

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

For renal failure

Use with caution in case of renal failure.

In case of liver dysfunction

Use with caution in case of liver failure.

Use during pregnancy and breastfeeding

During pregnancy, use is possible only for health reasons. It has a toxic effect on the fetus and increases the development of birth defects when used in the first trimester of pregnancy. When taken in therapeutic doses later in pregnancy, it may cause CNS depression in the newborn. Chronic use during pregnancy can lead to physical dependence with the development of withdrawal syndrome in the newborn. Children, especially young children, are very sensitive to the CNS depressant effects of benzodiazepines.

Use immediately before or during childbirth may cause respiratory depression in the newborn, decreased muscle tone, hypotension, hypothermia and weak sucking ("floppy baby" syndrome).

Drug interactions

When used simultaneously, phenazepam reduces the effectiveness of levodopa in patients with parkinsonism.

Phenazepam may increase the toxicity of zidovudine.

There is a mutual enhancement of the effect with the simultaneous use of antipsychotic, antiepileptic or hypnotics, as well as central muscle relaxants, narcotic analgesics, ethanol.

Microsomal oxidation inhibitors increase the risk of toxic effects. Inducers of microsomal liver enzymes reduce effectiveness.

Increases the concentration of imipramine in the blood serum.

When used simultaneously with antihypertensive drugs, the antihypertensive effect may be enhanced. Increased respiratory depression may occur during concomitant administration of clozapine.

IM or IV (stream or drip): for rapid relief of fear, anxiety, psychomotor agitation, as well as in vegetative paroxysms and psychotic states, initial dose - 0.5-1 mg, average daily dose - 3-5 mg, in severe cases - up to 7-9 mg.

Orally: for sleep disorders - 250-500 mcg 20-30 minutes before bedtime. For the treatment of neurotic, psychopathic, neurosis-like and psychopath-like conditions, the initial dose is 0.5-1 mg 2-3 times a day. After 2-4 days, taking into account effectiveness and tolerability, the dose can be increased to 4-6 mg/day. In cases of severe agitation, fear, and anxiety, treatment begins with a dose of 3 mg/day, quickly increasing the dose until a therapeutic effect is obtained. For the treatment of epilepsy - 2-10 mg/day.

For the treatment of alcohol withdrawal - orally, 2-5 mg / day or intramuscularly, 500 mcg 1-2 times / day, for vegetative paroxysms - intramuscularly, 0.5-1 mg. The average daily dose is 1.5-5 mg, divided into 2-3 doses, usually 0.5-1 mg in the morning and afternoon and up to 2.5 mg at night. In neurological practice, for diseases with muscle hypertonicity, 2-3 mg is prescribed 1-2 times a day. The maximum daily dose is 10 mg.

To avoid the development of drug dependence during a course of treatment, the duration of use of phenazepam is 2 weeks (in some cases, the duration of treatment can be increased to 2 months). When discontinuing phenazepam, the dose is reduced gradually.

Phenazepam: brief instructions for use

• The product eliminates pain in the temples due to spasmed vascular walls.
• The drug is used when an attack (convulsions) occurs.
• The medicine is intended for people with low mental performance.
• The drug helps evacuate products during synthesis - carbon dioxide.
• The medication is intended for use in cases of pathological neurophysiological reactions.
• The medicine is consumed to improve the ability to accept new situations when stress occurs.
• The medication helps prevent increased fragility connective tissue vessel.
• The drug is used in orthopedics (dysfunction of the skeletal and limb muscles, uncoordinated work of the lower extremities).
• Treatment measures the drug is prescribed as directed by a doctor after a final diagnosis has been made.
• Treatment with the drug is prescribed for patients who experience bloody thickening in the capillary network.
• The drug is prescribed after surgical treatment in patients.

Overdose and side effects of Phenazepam

• Changing emotional reactions
• Double objects (double vision)
• Disturbance of mental balance
• Skin coloration (redness, in some cases icteric)

Buying Phenazepam at an economical price from an online pharmacy website.

Prices medical supplies will unexpectedly please you.

Possibility of obtaining advice from pharmacy pharmacists by telephone.

Clarify information about the cost of the medicine, instructions for use or other necessary indicators.