Indapamide. Rapid pressure reduction with indapamide


Latin name: Indapamide
ATX code: CO3BA11
Active substance:
Manufacturer: Hemofarm, Serbia;
Ozon, Russia, etc.
Pharmacy leave condition: On prescription

Indications for use

The drug is prescribed for:

  • Chronic arterial hypertension various origins
  • Hypertension at all stages of development
  • At chronic insufficiency cardiac activity to eliminate water and sodium retention in the body (treatment of edematous syndrome).

The latest indications are unregistered, but in these diseases, "Indapamide" gives a quick and lasting positive effect.

You can find out everything about the stagnation of fluid in the body in the article:.

Release form and method of administration

The drug is available in the form:

  • Film-coated tablets with round shape and convex on both sides, the drug in tablet form has a rather unpleasant aftertaste
  • Long acting tablets
  • Capsule
  • Modified release tablets.

The dosage of 2.5 (0.0025) can be either in one tablet or in a capsule. 1.5 mg (0.0015) - in tablets with prolonged action. The drug is produced in blisters of 10 tablets in a cardboard box.

Indapamide tablets and dosage

The average price is from 40 to 70 rubles.

Indapamide tablet: round coated tablet, white color. Contains indapamide 2.5 mg. Each tablet contains, in addition to active ingredient, includes:

  • Lactose monohydrate
  • Crosspovidone
  • magnesium stearate
  • Povidone K 30
  • Sodium lauryl sulfate
  • Talc.

The shell consists of macrogol, hypromellose, talc and titanium dioxide.

Adults (including the elderly) are prescribed 1 tablet. The tablet is taken once a day (regardless of when it was last appointment food). Preferred time of use is in the morning.

The average price for capsules and modified tablets is from 100 to 480 rubles.

Capsules "Indapamide" and dosage

The capsule is transparent, while the color of natural gelatin is observed. The contents of the capsules are powder or a mixture of powder and granules from white to white with a creamy tint. The method of taking the drug in the form of capsules completely coincides with the scheme of administration in the form of tablets.

It is worth remembering that it is not necessary to chew the drug, it is swallowed whole and washed down with at least half a glass of pure non-carbonated water.

Duration of treatment

The course of treatment on average can be from 4 to 8 weeks. If during this time it is not reached positive result receive mode cannot be changed daily dose drugs do not increase), it is better, in addition to therapy, to choose a drug that has an antihypertensive effect and is not a diuretic.

Terms and conditions of storage

Store in a dark place out of the reach of small children. The shelf life is up to two years.

Pharmacological group and mechanism of action

Refers to antihypertensive drugs with diuretic and vasodilating effects. The main action of "Indapamide" is manifested in the vessels and tissues of the kidneys. The drug inhibits the reverse absorption of sodium in the cortical part of the nephron loop, which ensures an increase in the excretion of sodium, magnesium, calcium and chlorine in the urine. This feature of the mechanism of action of "Indapamide" stimulates a decrease blood pressure, and does not affect the amount of urine excreted.

In addition, the drug significantly reduces the sensitivity of the walls of blood vessels to the effects of angiotensin and norepinephrine, inhibits the penetration of calcium into the smooth muscle cells of the walls of vessels of various calibers, which increases their elasticity and reduces peripheral resistance.

Indapamide does not affect the metabolism of carbohydrates and lipids, and also reduces the synthesis of oxygen radicals (both free and stable).

When taken orally, it is quickly and completely absorbed into the bloodstream. The maximum concentration in the blood is reached two hours after the use of a conventional tablet or capsule and 12 hours after taking the drug with prolonged action.

Metabolized in hepatocytes (liver cells). A larger percentage of the drug is excreted in the urine (up to 80%), the rest is in the faeces. Completely excreted from the body within 26 hours.

Contraindications

The tool has quite a wide range contraindications, which include:

  • Severe disorders of the functioning of the liver
  • Chronic renal failure, especially in the case of anuria
  • Individual intolerance to the components of the drug
  • Acute cerebrovascular accident
  • Decompensated stage of diabetes
  • Presence of gout
  • The period of pregnancy and lactation
  • Age under 18
  • Insufficient concentration of potassium or nitrogen in the blood.

It is not recommended to take the drug after drinking alcohol. Professional athletes for the period of competition requiring doping control should also refuse "Indapamide" and its analogues, since they can give a positive test result.

For diabetes, pregnancy and lactation

Since the drug does not change the level of insulin and glucose in the blood, it is approved for use in diabetes (if the disease is in the decompensation stage).

For pregnant women and nursing mothers, the appointment of "Indapamide" is also contraindicated, since the active substance is able to penetrate the placental barrier and enter the composition of breast milk.

Side effects and overdose

When taking the drug may develop adverse reactions from various organs and systems:

  • Cardiovascular system - changes in the cardiogram, the development of arrhythmia, accelerated heartbeat, hypotension
  • Digestive tract - nausea, vomiting, stomach pain, stool disorders
  • Nervous system - headache, nervousness, sleep disorders
  • Urinary system - development of polyuria
  • Visual apparatus - visual impairment, development of conjunctivitis
  • The appearance of skin manifestations of allergic reactions (urticaria, itching, vasculitis)
  • Changes in some indicators of laboratory tests.

In addition, back pain and chest, decreased libido and potency, excessive sweating, a sharp weight loss, the development of exacerbations of chronic diseases, the body becomes more susceptible to infection.

An overdose is characterized by the appearance of nausea and vomiting, a sharp decrease in pressure, drowsiness, and impaired functioning of the urinary system. If you suspect an overdose of Indapamide, you should consult a doctor for symptomatic therapy.

Interaction with other drugs

When taken together with "Indapamide" anticoagulants and sympathomimetic agents, a weakening of their effectiveness is observed.

The hypotensive property of the drug increases with the simultaneous appointment of neuroleptics and tricyclic antidepressants with it. Simultaneous reception With ACE inhibitors poses a risk of severe hypotension.

It is forbidden to use "Indapamide" in conjunction with drugs that include lithium - it is possible to develop intoxication of the body.

What is better to take with Losartran - Indapamide or Hypothiazid

Losartran is an antihypertensive agent prescribed for arterial hypertension of various origins. The use of this drug with antihypertensive drugs increases the effect of its administration.

Unlike Indapamide, Hypothiazid can be taken by women during pregnancy to lower blood pressure, relieve edema and symptoms of toxicosis.

Analogues and synonyms

All the features of some analogues of "Indapamide" are presented below:

Balkanpharma, Bulgaria
Price from 60 to 150 rubles.

Indications for use: arterial hypertension, as well as water and sodium retention in chronic heart failure. Available in capsule form and tablets with a dosage of 0.0025.

pros

  • Has no bad taste
  • The capsule dissolves when it enters the digestive tract

Minuses

  • Contraindicated in patients with impaired renal function
  • Prohibited during pregnancy and lactation.

ZAO Canonpharma Production, Russia
Price from 100 to 130 rubles

Biconvex tablets with a dosage of 0.015, have a prolonged action. They are taken in the morning, the tablet is swallowed without chewing, and washed down with plenty of water.

  • The tool has a long-term effect
  • The effect is visible immediately after use.
  • When the dose is exceeded, the hypotensive effect does not increase.
  • When used together with preparations containing lithium, symptoms of an overdose may appear (nephrotoxic effect - damage to the kidneys by a toxin).


"Indapamid MV Shtada"

Marquis Pharma, Russia
Price from 45 to 135 rubles.

Diuretic antihypertensive agent of prolonged action, which has the ability to reduce and stabilize high blood pressure. Round coated tablets yellow color and are characterized by modified release.

pros

  • When taking the drug, jumps blood pressure to critical low scores and vice versa are almost impossible.
  • It has a protective effect on the vessels of target organs, which are most often affected in hypertension

Minuses

  • The drug works slowly
  • The first week of admission is due to many side effects (nausea, abdominal pain, etc.).

Pro.Med.CS, Czech Republic
Price from 65 to 120 rubles.

Reduces the tone of the smooth muscles of the arteries and the total peripheral resistance. Available in capsule form (hard gelatin)

pros

  • Effectively used to treat hypertension in people with comorbidities (renal failure, hyperlipidemia)
  • Increases the elasticity of arterial walls and helps to reduce left ventricular hypertrophy

Minuses

  • Use with caution in diabetes mellitus (increases the required dose of insulin)
  • Shown in doping tests.


Servier, France
Price from 280 to 470 rubles.

They have a diuretic and hypotensive effect. Tablets with a dosage of 0.0025 and 0.0015

pros

  • When the dose is exceeded (up to 40 mg, i.e. 27 times more than the therapeutic dose), the drug does not have a toxic effect
  • The positive effect after the course of treatment lasts up to six months

Minuses

  • Not to be taken during pregnancy and lactation
  • Dries mucous membranes and causes thirst
  • It should not be taken by people with lactose intolerance (this substance is included in the composition).

Indapamide is an effective drug that affects the state of the kidneys and resembles the structure of a thiazide diuretic. It has a diuretic effect, and also helps to lower blood pressure, from which Indapamide is mainly used to treat arterial hypertension.

This drug reduces the total peripheral vascular resistance, lowers the tone of the smooth muscles of the arteries, resulting in high blood pressure is reduced to normal level. As a rule, the hypotensive effect of taking this drug appears only in the case of initial high blood pressure and develops within a week of systematic use. The maximum effect of the use of this drug is achieved after three months of regular and correct intake. Indapamide is rapidly and completely absorbed from digestive tract when you take this drug on an empty stomach. In the case of taking this drug with food, the rate of its absorption is significantly slowed down, as a result of which it has therapeutic effect comes a little later.

What do Indapamide tablets help with?

  • This drug is used when it is necessary to reduce blood pressure without a significant effect on the volume of urination.
  • Indapamide tablets stimulate the formation of platelet aggregation blockers: prostaglandin PgE2 and prostacyclin PgI2, as well as vasodilators, which has a positive effect on reducing the total precardiac load, dilating arterioles and reducing blood pressure. Therefore, this drug is prescribed for people suffering from high blood pressure.

Despite the mass positive properties this drug, there are the following contraindications to its reception:

  • obvious violations of hepatic functions, including hepatic encephalopathy;
  • gout;
  • renal failure in the presence of anuria;
  • intolerance to the main component of this drug - indapamide;
  • children's age up to 18 years;
  • period of pregnancy and lactation;
  • recent cerebrovascular accident;
  • hypokalemia, etc.

Method of application and dosage

This medicine should be taken by mouth, preferably in the morning. Indapamide should be swallowed whole with a sufficient amount of liquid. Recommended dosage this drug is 2.5 grams. If after 4 to 8 weeks of treatment the desired therapeutic effect is not achieved, another treatment should be added to the treatment regimen. antihypertensive drug which is not a diuretic. Remember that the dose of this drug should not be exceeded, as there is a possibility of side effects.

Drug interactions with other drugs

  • With the simultaneous use of this drug with ACE inhibitors, the risk of developing hyponatremia increases.
  • When using the drug with drugs containing calcium, hypercalcemia may develop due to a decrease in the excretion of calcium ions in the urine.
  • In case of application this medicine together with NSAIDs, it is possible to reduce the hypotensive effect of Indapamide. With a large loss of fluid, there is a risk of developing acute renal failure.
  • At joint application taking this medicinal product with cardiac glycosides and corticosteroids increases the risk of hypokalemia.
  • In the case of the use of Indapamide with tricyclic antidepressants, the hypotensive effect increases, and the risk of orthostatic hypotension increases.
  • When this drug is used together with terfenadine, astemizole, pentamidine, erythromycin (in / in), disopyramide, there is a risk of developing an arrhythmia of this type, such as "pirouette".
  • In the case of simultaneous use of this drug with baclofen, the hypotensive effect increases.
  • With simultaneous use with lithium carbonate, the risk of developing a toxic effect of lithium against the background of a decrease in its renal clearance increases significantly.

Indapamide is an effective diuretic, most commonly used in the treatment of hypertension. Unlike similar medical preparations, this medicine works quickly at a lower dosage. It allows you to quickly normalize high blood pressure, does not have a negative effect on metabolism, as well as on the content of glucose, insulin and cholesterol in the blood, for which Indapamide is widely used in modern medicine.

Indapamide: instructions for use and reviews

Latin name: Indapamide

ATX code: C03BA11

Active substance: indapamide (indapamide)

Producer: Teva (Israel), Valenta Pharmaceuticals JSC, PRANAPHARM LLC (Russia), STADA Artsnaimittel (Germany), Hemofarm (Serbia and Montenegro), Tianjin Pacific Chemical & Pharmaceutical Co. Ltd (China), Stoma JSC (Ukraine)

Description and photo update: 13.05.2018

Indapamide is a drug with vasodilating, hypotensive and diuretic effects.

Release form and composition

Indapamide is produced in the following dosage forms:

  • Capsules (5 pcs in blister packs, 4 packs in a carton pack; 6 pcs in blister packs, 5 packs in a carton pack; 7 pcs in blister packs, 2 packs in a carton pack; 10 pcs in blister packs, 1-5 packs in a carton pack, 30 pcs in blister packs, 1-4 packs in a carton pack, 10, 20, 30, 40, 50, 100 pcs. in banks, 1 bank in a cardboard bundle);
  • Prolonged-release tablets, film-coated (10 pieces in blisters, 2, 3, 6 blisters in a carton box; 30 pieces in jars, 1 jar in a carton box);
  • Coated tablets with modified release (10 and 14 pieces in blister packs, 1, 2, 3, 100, 200, 300, 400, 500 packs in a carton box);
  • Film-coated tablets (20, 30 pieces in polyethylene bottles or jars, 1 bottle or jar in a carton box; 10, 20, 30 pieces in blister packs, 1-6, 8, 10, 20, 40, 60, 80, 100 packs in a carton pack, 10 pcs in polymer containers, 1, 10, 20, 30, 40, 50, 100 containers in a carton pack, 20, 30, 40, 50 pcs in a carton polymer containers, 1, 10, 20 containers in a cardboard box);
  • Film-coated tablets (10, 20 pieces in blisters, 1-5 blisters in a carton box; 30, 50 pieces in blisters, 1-3 packs in a carton box; 10, 20, 25 , 30, 50, 500, 1000 pieces in a polyethylene bottle, 1 bottle in a cardboard box).

The composition of the drug includes the active substance - indapamide:

  • Tablets of prolonged action and tablets with modified release, coated - 1.5 mg;
  • Capsules, film-coated tablets and film-coated tablets - 2.5 mg.

Auxiliary components:

  • Capsules: microcrystalline cellulose, magnesium stearate;
  • Long-acting film-coated tablets: lactose monohydrate, hypromellose, magnesium stearate, anhydrous colloidal silicon dioxide;
  • Coated tablets: polyethylene glycol, lactose monohydrate (Type 312), lactose monohydrate (Spray-Dried), microcrystalline cellulose, magnesium stearate, sodium croscarmellose;
  • Film-coated tablets: lactose monohydrate, povidone K30, crospovidone, magnesium stearate, sodium lauryl sulfate, talc.

Pharmacological properties

Pharmacodynamics

Indapamide is a derivative of a sulfonamide, and its pharmacological properties similar to those of thiazide diuretics. It is characterized by saluretic and diuretic effects of moderate severity associated with a slowdown in the reabsorption of chloride, sodium and, to a lesser extent, magnesium and potassium ions in the cortical segment of the distal nephron tubule and in the proximal renal tubules.

Indapamide can reduce the tone of the smooth muscles of the arteries and has a vasodilating effect, and also provides a decrease in the total peripheral resistance vessels. These effects are due to a decrease in the reactivity of the walls of blood vessels to angiotensin II and norepinephrine, inhibition of calcium current in the cells of vascular smooth muscles, and activation of the production of prostaglandin E2 in the body, which is characterized by a vasodilating effect.

When using indapamide, a decrease in left ventricular hypertrophy of the heart is observed. The substance exhibits antihypertensive properties when taken in doses that do not have a pronounced diuretic effect.

For thiazide and thiazide-like diuretics, after exceeding a certain therapeutic dose, the formation of a plateau is characteristic. therapeutic effect, while the severity of unwanted adverse reactions continues to grow. Therefore, it is not recommended to increase the dose of indapamide if the therapeutic effect is not achieved when taking the drug at the recommended dose.

With the systematic use of the drug, the therapeutic effect is observed 1-2 weeks after the start of treatment, reaches a peak by 8-12 weeks and lasts up to about 8 weeks. After a single dose of indapamide maximum effect registered after 24 hours.

Pharmacokinetics

After oral administration, indapamide is rapidly and almost 100% absorbed from the gastrointestinal tract. Eating slightly reduces the rate of absorption, but does not affect its completeness. After a single dose of the drug, the maximum concentration of the active ingredient in the blood plasma is determined after 0.5-2 hours.

The degree of binding of indapamide to plasma proteins is approximately 76-79%. Since the substance has a high affinity for elastin, it mainly accumulates in the smooth muscles of the walls of blood vessels. Indapamide also reacts with erythrocyte carbonic anhydrase without inhibiting the activity of this enzyme. The drug is metabolized in the liver, and its equilibrium concentration is determined after 7 days of regular intake. Repeated use of indapamide does not lead to its accumulation in the body. The substance has a large volume of distribution, overcomes histohematic barriers, including placental, and is determined in breast milk.

Indapamide is excreted largely in the urine (60-70% of the dose) and faeces (16-20%) as pharmacologically inactive metabolites. About 7% of the active substance is excreted unchanged. The half-life is 14-18 hours. In patients with renal insufficiency, the pharmacokinetic parameters of indapamide remain unchanged.

Indications for use

According to the instructions, Indapamide is prescribed for the treatment of arterial hypertension.

Contraindications

  • Severe renal failure (in the stage of anuria);
  • Expressed liver failure(including with encephalopathy);
  • Galactosemia;
  • hypokalemia;
  • Glucose/galactose malabsorption syndrome, lactose intolerance;
  • Simultaneous administration with drugs that prolong the QT interval;
  • Pregnancy and lactation;
  • Age up to 18 years (safety and efficacy of the drug for this age group of patients have not been established);
  • Hypersensitivity to the components of the drug, as well as to other sulfonamide derivatives.

Indapamide should be taken with caution in patients with functional impairment of the kidneys and / or liver, diabetes in the stage of decompensation, hyperuricemia (especially accompanied by urate nephrolithiasis and gout), fluid and electrolyte imbalance, hyperparathyroidism, with an increased QT interval on the ECG or receiving other antiarrhythmic drugs.

Instructions for use Indapamide: method and dosage

Indapamide is taken orally, once, in the morning, without chewing and drinking a sufficient amount of liquid.

The daily dose of the drug is 1 tablet (in the form of prolonged-release tablets and modified-release coated tablets - 1.5 mg; capsules, coated tablets and film-coated tablets - 2.5 mg). If after 1-2 months of therapy the desired therapeutic effect is not achieved, it is not recommended to increase the dose of Indapamide (due to the increased risk of side effects without enhancing the antihypertensive effect). In these cases, in the scheme drug treatment another non-diuretic antihypertensive drug should be included. When taking two different drugs, the dose of Indapamide should not be adjusted (1 tablet per day, once, in the morning).

Side effects

While taking Indapamide, it is possible to develop disorders from some body systems:

  • Cardiovascular system: orthostatic hypotension, arrhythmia, ECG changes (hypokalemia), palpitations;
  • Central nervous system: nervousness, asthenia, headache, drowsiness, dizziness, insomnia, vertigo, depression; rarely - malaise, general weakness, fatigue, muscle spasm, irritability, tension, anxiety;
  • Digestive system: abdominal pain, nausea, dry mouth, anorexia, vomiting, gastralgia, diarrhea, constipation, hepatic encephalopathy may develop; rarely - pancreatitis;
  • Urinary system: nocturia, frequent infections, polyuria;
  • Respiratory system: sinusitis, pharyngitis, cough; rarely - rhinitis;
  • Hematopoietic system: very rarely - leukopenia, thrombocytopenia, agranulocytosis, hemolytic anemia and aplasia of the bone marrow;
  • Laboratory indicators: hypercalcemia, hyperuricemia, hypokalemia, hyperglycemia, hyponatremia, hypochloremia, increased plasma urea nitrogen, glucosuria, hypercreatininemia;
  • Allergic reactions: hemorrhagic vasculitis, urticaria, rash, itching;
  • Others: exacerbation of the course of systemic lupus erythematosus.

Overdose

An overdose of Indapamide can be determined by symptoms such as polyuria or oliguria up to anuria (due to hypovolemia), a pronounced decrease in blood pressure, depression of the respiratory center, water and electrolyte disorders(hypokalemia, hyponatremia), lethargy, drowsiness, confusion, dizziness, seizures, nausea, vomiting. Patients diagnosed with cirrhosis of the liver may develop hepatic coma.

special instructions

Elderly patients and patients taking laxatives and cardiac glycosides against the background of hyperaldosteronism should regularly monitor the content of potassium ions and creatinine.

During therapy, it is necessary to systematically monitor the concentration of sodium, magnesium and potassium ions in the blood plasma (due to possible electrolyte disturbances), pH, glucose concentration, residual nitrogen and uric acid. The first study of the concentration of potassium in the blood is carried out during the first 7 days of treatment.

Also, the high-risk group includes patients with an increased QT interval on the ECG (developing against the background of any pathological process or congenital).

Patients with cirrhosis of the liver (especially with ascites or edema, which is associated with the risk of developing metabolic alkalosis, which increases the severity of hepatic encephalopathy), heart failure, ischemic disease heart and elderly patients.

Hypercalcemia that developed during the use of Indapamide may indicate the presence of previously undiagnosed hyperparathyroidism.

It is necessary to control the level of glucose in the blood in patients with diabetes mellitus, especially with hypokalemia.

Significant dehydration can lead to acute renal failure (reduced glomerular filtration rate). Patients should be compensated for water loss and carefully monitor renal function at the start of therapy.

When conducting a doping control, Indapamide can give a positive result.

In case of arterial hypertension and hyponatremia (associated with taking diuretics), it is necessary to stop taking diuretics 3 days before the start of taking angiotensin-converting enzyme inhibitors (if necessary, diuretics can be resumed a little later), or prescribe initial angiotensin-converting enzyme inhibitors in low doses.

Sulfonamide derivatives can cause an exacerbation of the course of systemic lupus erythematosus (must be taken into account when prescribing Indapamide).

In some cases, individual reactions are possible during therapy, which are associated with changes in blood pressure, especially at the beginning of therapy and when another antihypertensive drug is added. Because of this, the ability to drive a car and perform tasks that require increased attention may decrease.

Use during pregnancy and lactation

The use of Indapamide in pregnant women is not recommended. Its reception can provoke the development of fetoplacental ischemia, which can slow down the development of the fetus.

Since indapamide penetrates into breast milk, it should not be prescribed during lactation. If it is necessary to take the drug by nursing patients, breastfeeding should be discontinued.

drug interaction

With the simultaneous use of Indapamide with some medicines unwanted effects may occur:

  • Saluretics, laxatives, cardiac glycosides, tetracosactide, gluco- and mineralocorticoids, amphotericin B (intravenously): increased risk of hypokalemia;
  • Cardiac glycosides: an increase in the likelihood of developing digitalis intoxication;
  • Erythromycin (intravenously), astemizole, pentamidine, vincamine, terfenadine, sultopride, antiarrhythmic drugs Class I A (disopyramide, quinidine) and class III (bretylium tosylate, amiodarone, sotalol): development of arrhythmia of the "pirouette" type (torsades de pointes);
  • Non-steroidal anti-inflammatory drugs, tetracosactide, glucocorticosteroids, sympathomimetics: decreased hypotensive effect;
  • Calcium preparations: an increase in the likelihood of developing hypercalcemia;
  • Antipsychotics and imipramine (tricyclic) antidepressants: increased hypotensive effect and increased risk of orthostatic hypotension;
  • Cyclosporine: increased risk of hypercreatininemia;
  • Metformin: increased likelihood of worsening lactic acidosis;
  • Angiotensin-converting enzyme inhibitors: increased risk of acute renal failure and/or arterial hypotension(especially with existing renal artery stenosis);
  • Iodine containing contrast media high doses: an increase in the risk of developing impaired renal function (dehydration is possible, before using iodine-containing substances, patients need to restore fluid loss);
  • Baclofen: increased hypotensive effect;
  • Potassium-sparing diuretics: the development of hyper- or hypokalemia, especially in patients with renal insufficiency and diabetes mellitus (in some categories of patients, this combination may be effective);
  • Indirect anticoagulants (derivatives of indandione or coumarin): a decrease in their effect (dose adjustment may be required);
  • Non-depolarizing muscle relaxants: increased blockade of neuromuscular transmission that develops under their action.

Indapamide increases the concentration of lithium ions in the blood plasma (decreased excretion in the urine), lithium has a nephrotoxic effect.

Analogues

Analogues of Indapamide are: Indapamide Retard, Indapamide-Teva, Indapamide MV Stada, Arifon Retard, Indap, Ionic, Tenzar, Indapen, Lorvas, Acrylamide, Indopres, Hydrochlorothiazide, Oxodoline, Cyclomethiazide.

Terms and conditions of storage

Store in a dry, dark place, out of the reach of children.

Best before date:

  • Capsules, prolonged-release film-coated tablets, modified-release film-coated tablets - 2 years at temperatures up to 25 ° C;
  • Film-coated tablets - 3 years at a temperature of 15-30 ° C;
  • Film-coated tablets - 4 years at a temperature of 15-25 ° C.

The diuretic drug "Indapamide" is able to effectively reduce blood pressure. At the same time, normalization occurs gently, and the diuretic effect is minimal. The drug has cumulative properties. The maximum result is observed after 8-10 weeks after the start of use. The medication has a list of contraindications and side effects. To prevent the latter, you should consult a doctor and carefully monitor your well-being.

Composition, properties and form of release

Tablets "Indapamide" belong to the group of diuretics and drugs for hypertension. The main actions include a smooth decrease in pressure. Wherein diuretic effect controllable, which helps prevent dehydration and keeps the balance of substances normal. Externally, the tablets are white or slightly grayish in color, round, film-coated. The action of "Indapamide Retard" is due to the presence active substance indapamide. The pills contain 2.5 mg of the drug. The tablets also contain:

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Mechanism of action


The drug effectively lowers blood pressure.

The action of "Indapamide" on the body is based on the increased excretion of elements of sodium and chlorine from the blood. Wherein medicinal product practically does not affect the concentration of potassium and magnesium. As a result, there is a decrease in blood pressure and a slight diuretic effect is observed. The value of the reduced pressure does not depend on the amount of the drug taken. As the dose increases, the amount of liquid released changes. The medicine is characterized by a cumulative effect. If you constantly take "Indapamide" for 8-12 weeks, then maximum result from treatment.

Why is Indapamide prescribed?

Indications for use describe situations in which the use of the remedy brings maximum benefit and result. The diuretic drug is widely used for high blood pressure. Assign "Indapamide" as an independent agent or as an addition to complex therapy. If the patient does not have hypertension, taking pills causes a deterioration in the condition and the manifestation of adverse reactions.

Instructions for use and dosage


During treatment, it is recommended to follow the doctor's prescriptions according to the instructions.

Drink diuretics should be strictly according to the schedule indicated by the doctor. "Indapamide" can be taken before or after meals. For high blood pressure, 1 tablet in the morning is recommended. In the evening, the medicine is not taken, since "Indapamide" refers to diuretic drugs. If necessary, it is allowed to drink the pill with a small amount of liquid. The result begins to appear no earlier than 2-3 weeks after the start of therapy. It has to do with cumulative action. If the duration of admission exceeds 4-5 weeks, but there is no effect, the drug should be discontinued or the daily dosage should be reviewed.

Use during pregnancy and lactation

"Indapamide" from pressure should be taken according to the doctor's recommendations. In this case, all risk factors should be taken into account. These include the period of gestation. Taking the drug in this case is dangerous. "Indapamide" during pregnancy has the ability to penetrate the placenta to the fetus. At the same time, the diuretic reduces blood pressure and provokes oxygen starvation. Instructions for use prohibits the use of a diuretic during breastfeeding. "Indapamide" is harmful to infants, as it penetrates into mother's milk. If a woman needs to take the remedy, then for the duration of therapy, feeding is replaced with artificial.

Is it for children?


The drug is not recommended for children, there is a risk of lowering blood pressure.

The use of "Indapamide" to a child in the presence of the disease is not recommended. It is forbidden to use due to the lack of experimentally confirmed evidence of the safety of the product. Application can provoke cases low pressure in a minor patient. In case of illness, it is better to resort to alternative drugs. There is an option to use the remedy every other day with a minimum daily dose and with high blood pressure.

Contraindications

"Idapamide" drink with caution at the beginning of treatment. This is due to the presence of a list of prohibited diseases. The consequence of ignoring the list are obvious side effects. Over time, they develop into health complications. Do not use at low pressure and gout. Among other contraindications to taking "Indapamide tab":

  • negative reactions to the composition;
  • age up to 18 years;
  • taking incompatible drugs;
  • circulatory disorders in the brain;
  • urinary disorders;
  • kidney failure;
  • low levels of potassium in the body.

How to understand what an overdose?


An overdose of the drug can cause weakness in the body, drowsiness and disturbances in the digestive tract.

Taking the medicine for a long time without the supervision of a doctor or with violations of the prescribed dosages is fraught with the onset of an overdose. Long-term use with disorders is characterized by nausea, hypotension, weakness, drowsiness and disturbances in the work of the stomach. In this case, the balance of substances in the body is quickly disturbed. If you stop and start using the drug correctly, taking into account the prescribed dosage, you can avoid dangerous consequences. It is possible to reduce the concentration of indapamide in the blood by washing. Activated carbon or other sorbents act similarly.

Indapamide is a loop diuretic that increases the excretion of sodium and chloride ions from blood plasma. Reduces the amount of plasma, prevents its reverse filtration, which leads to an increase in the amount of secondary urine. It has a pronounced hypotensive effect due to the loss of excess fluid. Used to treat hypertension in early stages, as well as as part of complex therapy in the treatment of its complications and concomitant diseases heart and kidneys. Easily tolerated by patients with a single daily intake, does not cause resistance and does not negative impact to other organs and systems.

1. Pharmacological action

Non-potassium-sparing diuretic drug of medium potency. Lowers blood pressure (by reducing vascular tone) and helps reduce overall resistance vascular wall peripheral arteries (due to a decrease in the sensitivity of the vascular wall to the effects of adrenaline and an increase in the synthesis of prostaglandins).

A decrease in blood pressure is observed only when initially increased rates one week after the first dose and reaches its maximum after 3 months of treatment.

After oral administration, the drug is rapidly and completely absorbed, almost completely binding to plasma proteins and reaching its maximum concentration after 2 hours. It does not have the ability to form clusters, It is excreted by the kidneys after 36 hours in the form of decay products.

2. indications for use

  • Long boost blood pressure;
  • Phenomena of stagnation of fluid and sodium ions in chronic functional heart failure.

3. How to use

The drug should be used in the morning on an empty stomach, without chewing and grinding with any other accessible way and drinking plenty of warm drinking water.

Application Features:

  • During the use of the drug, monitoring of the percentage of electrolytes is necessary;
  • Increasing the dosage only affects the increase in the diuretic effect of Indapamide;
  • Before using the drug, a number of studies should be carried out in order to identify conditions of electrolyte imbalance.
The drug is taken with caution in the following conditions:
  • Diabetes mellitus (the use should be accompanied by constant monitoring of blood glucose levels);

4. Side effects

  • Violations digestive system(stool disorders, nausea, inflammation of the pancreas, feeling of dry mouth, functional disorders liver activity)
  • Violations nervous system(headaches, general weakness, involuntary muscle contractions, muscle pain, fatigue, dizziness);
  • Violations respiratory system(inflammation of the paranasal sinuses, inflammation of the larynx, cough);
  • Violations of the hematopoietic system (various changes in the percentage of blood cells);
  • Violations of cardio-vascular system(violations heart rate, sharp decline blood pressure);
  • Various allergic reactions(systemic lupus erythematosus, occurring in the acute stage, skin rashes, purpura);
  • Violations of various clinical indicators(decrease in the content of potassium ions, an increase in the content of calcium ions, a decrease in the content of chlorine ions, an increase in the content of uric acid, a delay in the orthostatic reflex (change in pressure when changing body position)).

5. Contraindications

6. During pregnancy and lactation

Despite the fact that there have been no reliable studies confirming or refuting the negative effect of the drug on the body of the mother or child, the use of Indapamide at all stages of pregnancy Not recommended.

If necessary, the drug can be used during the period breastfeeding only after its complete cessation throughout the treatment, until the complete removal of decay products from the mother's body.

7. Interaction with other drugs

  • Simultaneous use with drugs that block the ACE enzyme, the risk of developing sharp decline the level of concentration of sodium ions;
  • Simultaneous use with hormonal drugs cortical zones of the adrenal glands and anti-inflammatory drugs of a non-steroidal nature, the therapeutic effect of Indapamide associated with a decrease in blood pressure decreases;
  • Simultaneous use with drugs containing calcium ions in their composition leads to an increased content of calcium ions in the body;
  • Simultaneous use with cardiac glycosides, hormonal preparations of the adrenal cortex or any other drugs that increase the excretion of potassium ions from the body, a decrease in the concentration of potassium ions is observed;
  • Simultaneous use with tricyclic antidepressants leads to an increase in the therapeutic effect of Indapamide, associated with a decrease in blood pressure;
  • Simultaneous use with Halofantrine, Terfenadine, Quinidine, Vincamine, Pentamidine, Bepridil, Astemizole, Sotalol, Sultopride, Erythromycin, Disopyramide and Amioradon leads to the development of cardiac arrhythmias;
  • simultaneous use with Lithium Carbonate, there is a development side effects associated with high content lithium ions in the body;
  • Simultaneous use with Cyclosporine, there is an increase in creatinine levels;
  • Simultaneous use with Metformin leads to the development of functional kidney failure and the subsequent development of a shift in acid-base balance to the left.

8. Overdose

Overdose symptoms develop when the drug is used at a dosage that is 40 times the recommended one.
  • Digestive system disorders (nausea, vomiting);
  • Nervous system disorders (drowsiness, dizziness);
  • urinary tract disorder ( various violations formation and excretion of urine).
If these conditions occur, patients are recommended gastric lavage, the use of activated carbon or similar drugs in a slightly overdose and medical treatment of symptoms. All procedures must be carried out only in medical institutions under the supervision of medical personnel.

9. Release form

Capsules, 2.5 mg - 10, 14, 20, 24 or 30 pcs.
Film-coated tablets, 2.5 mg - 10, 20, 30, 40 or 50 pcs.
Tablets of prolonged action, film-coated, 1.5 mg - 20, 30 or 60 pcs.

10. Storage conditions

special instructions no.

11. Composition

1 tablet:

  • indapamide - 2.5 mg;
  • Excipients: pregelatinized starch, microcrystalline cellulose, colloidal silicon dioxide (aerosil), magnesium stearate, hypromellose, macrogol, lactose monohydrate, titanium dioxide.

1 capsule:

  • indapamide - 2.5 mg.

12. Terms of dispensing from pharmacies

The drug is released according to the prescription of the attending physician.

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*Instruction for medical use for Indapamide is published in free translation. THERE ARE CONTRAINDICATIONS. BEFORE USE, IT IS NECESSARY TO CONSULT WITH A SPECIALIST

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